Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer.
By J. Y. Sagiv, Janna Michaeli, Simaan Assi, Inbal Mishalian, Hen Kisos, Liran Levy, Pazzit Damti, D. Lumbroso, L. Polyansky, Ronit Vogt Sionov and 5 more. Cell Reports, 2015
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Controversy surrounds neutrophil function in cancer because neutrophils were shown to provide both pro- and antitumor functions. We identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation but accumulate continuously with cancer progression. LDNs display impaired neutrophil function and immunosuppressive properties, characteristics that are in stark contrast to those of mature, high-density neutrophils (HDNs). LDNs consist of both immature myeloid-derived suppressor cells (MDSCs) and mature cells that are derived from HDNs in a TGF-β-dependent mechanism. Our findings identify three distinct populations of circulating neutrophils and challenge the concept that mature neutrophils have limited plasticity. Furthermore, our findings provide a mechanistic explanation to mitigate the controversy surrounding neutrophil function in cancer.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/18e76cfd3251aa5d5e039dd89d19cd805a097d63
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In Immunology
Citations in the corpus
- EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, neutral): “Neutrophils can exist in distinct and dynamically changing phenotypic states that can be shaped by the primary tumor as well as other host cells (Coffelt et al., 2016; Fridlender et al., 2009; Sagiv et al., 2015).”
- Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “In contrast, in presence of TGF-β, had a protumor (N2) phenotype.”