Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer
By Bowen Du, J. Shim. Molecules, 2016
728 citations recorded by the source corpus.
Epithelial–mesenchymal transition (EMT) is known to play an important role in cancer progression, metastasis and drug resistance. Although there are controversies surrounding the causal relationship between EMT and cancer metastasis, the role of EMT in cancer drug resistance has been increasingly recognized. Numerous EMT-related signaling pathways are involved in drug resistance in cancer cells. Cells undergoing EMT show a feature similar to cancer stem cells (CSCs), such as an increase in drug efflux pumps and anti-apoptotic effects. Therefore, targeting EMT has been considered a novel opportunity to overcome cancer drug resistance. This review describes the mechanism by which EMT contributes to drug resistance in cancer cells and summarizes new advances in research in EMT-associated drug resistance.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/69a9b5e409f2acbc23996ff1a60afe16560c3edf
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In Molecular Biology
Citations in the corpus
- Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment (2018, background): “Lately, the finding of therapeutic agents to EMT-based CSC therapy indicated three general target groups [184, 185].”
- Drug resistance and combating drug resistance in cancer (2019, background): “One possible mechanism is that EMT cells share many similarities in signaling pathways with cancer stem cells (CSCs), such as Wnt, Notch and Hedgehog pathways([123]).”