Inflammatory proteins in plasma and the risk of dementia: the rotterdam study.

By M. Engelhart, M. Geerlings, J. Meijer, A. Kiliaan, A. Ruitenberg, J. V. van Swieten, Theo Stijnen, Albert Hofman, J. Witteman, Monique M. B. Breteler. Archives of Neurology, 2004

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Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, neutral): “Higher plasma levels of the inflammatory marker a1-antichymotrypsin and IL-6 (Engelhart et al., 2004), as well as higher spontaneous production of IL-1 or TNFa by peripheral blood mononuclear cells (Tan et al.”
Frailty: an emerging research and clinical paradigm--issues and controversies. (2006, background): “Increased levels of inflammatory cytokines are also associated with both a lower Mini-Mental State Examination score (39) and an increased risk of developing dementia (40,41).”
Molecular Inflammation: Underpinnings of Aging and Age-related Diseases (2008, background): “In this study, elevated CRP levels were related to a significantly increased risk for vascular dementia (VaD) and AD, with or without cardiovascular disease (CVD) contributing to the dementia.”
Systemic infections and inflammation affect chronic neurodegeneration (2007, result): “Inflammatory proteins in the plasma, notably C-reactive protein and IL-6, were found to be increased 5 years before the clinical onset of dementia in several studies, compared with age-matched individuals who did not go on to develop dementi”
Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group (2013, neutral): “C-reactive protein (CRP) and Interleukin-6 (IL-6)] (28, 75, 76-78).”