Nitric oxide synthases: structure, function and inhibition.

By W. Alderton, Chris E. Cooper, Richard Graham Knowles. Biochemical Journal, 2001

4,113 citations recorded by the source corpus.

Subfields: Biophysics, Inorganic Chemistry, Physiology

View Paper: https://www.semanticscholar.org/paper/26d7eaf5dedce2669648efe700706c52c4dd7460

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In Biophysics

1. S. Perwez Hussain
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4. Paola Zanovello

In Inorganic Chemistry

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Citations in the corpus

• iNOS-mediated nitric oxide production and its regulation. (2004, background): “The C-terminal reductase domain of NOS displays close homology with cytochrome P450 reductase and transfers NADPH-derived electrons that are required for reductive activation of molecular oxygen to the N-terminal oxygenase domain, resulting in oxygen insertion into L-arginine and NOHarginine (Aldert”
• The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance (2008, background): “…in mammalian cells by three distinct NO synthases (nNOS, iNOS and eNOS), and regulates multiple physiological functions including vascular tone, platelet aggregation, smooth muscle relaxation, and synaptic function, as well as cytotoxicity of the innate immune system (Alderton et al. 2001).”
• Flower bud opening and senescence in roses (Rosa hybrida L.) (2008, background): “L-citrulline in presence of NADPH and oxygen (Alderton et al. 2001).”
• Concepts of neural nitric oxide-mediated transmission (2008, background): “All three isoforms generate NO from l-arginine but have distinct functional and structural features (reviewed by Alderton et al., 2001; Stuehr et al., Correspondence: Dr J. Garthwaite, as above.”
• Inflammation and cancer: An ancient link with novel potentials (2007, methodology): “thase (NOS), which catalyzes the conversion of L-arginine to citruline and uses molecular oxygen and NADPH as cofactors.(25,26)”
• Inducible Nitric Oxide Synthase: Regulation, Structure, and Inhibition (2019, background): “nNOS is primarily found in the nervous system and is necessary for neuronal signaling, while eNOS is localized to the endothelium and is essential for vasodilation and control of blood pressure.(1) These two isoforms produce nanomolar amounts of NO for short periods of time (seconds to minutes) in a”
• Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. (2018, background): “Electrons are transferred from NADPH, bound to the C-terminal reductase domain, to the heme iron and the cofactor tetrahydrobiopterin (BH4) in the N-terminal oxygenase domain, in order to reduce and incorporate O2 into L-arginine, thus generating NO and citrulline [1, 2, 55].”
• Nitric oxide synthases: regulation and function. (2012, background): “However, a focus of the article will be on eNOS and functions of NO in the cardiovascular system. cofactor BH 4 , molecular oxygen, and the substrate L -arginine 14,15 ( Figure 2 ).”
• Regulation of immune responses by L-arginine metabolism (2005, background): “fcgi?db=genec NOS2 (also known as iNOS) is the inducible isoform, which is present in various cells of the immune system, including several types of myeloid cell; and NOS3 (also known as eNOS) is found in endothelial cell”