A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

By Carola G. Vinuesa, M. Cook, C. Angelucci, V. Athanasopoulos, L. Rui, K. Hill, Di Yu, Heather Domaschenz, Belinda Whittle, T. Lambe and 5 more. Nature, 2005

884 citations recorded by the source corpus.

Subfields: Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/26abbbbd4ee108b375d500b890256bb7b3d27a3f

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Citations in the corpus

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion (2011, background): “Furthermore, although several mouse studies show that over- representation of Tfh cells is associated with the development of systemic autoimmunity (Linterman et al., 2009; Subramanian et al., 2006; Vinuesa et al., 2005), their association with human autoimmune diseases remains largely unknown.”
T follicular helper (TFH) cells in normal and dysregulated immune responses. (2008, background): “These T cells resemble human TFH cells in that they express high levels of ICOS, CXCR5, CD200 and PD1 and transcripts for IL-21 (53).”
Germinal Center Dynamics Revealed by Multiphoton Microscopy Using a Photoactivatable Fluorescent Reporter (2010, background): “This notion is supported by previous work showing that dysregulated T cell help can lead to faulty GC selection and to the emergence of autoantibody-producing B cells (Vinuesa et al., 2005a; Kim et al., 2010).”
Follicular Helper T Cells. (2016, background): “Roquin (also known as Roquin1, encoded by Rc3h1) was the first RNAbinding protein shown to repress Tfh cell accumulation (46).”
FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION (2009, background): “In mouse, gene expression studies of Tfh cells associated with overexpression of ICOS also identified IL-21 and CD200 as preferentially abundant in Tfh cells (Vinuesa et al., 2005a) with Tfh gene expression clustering distinctly when compared to Th1, Th2, and Th17 cells (Nurieva et al., 2008).”
Generation of follicular helper T cells is mediated by IL-21 but independent of TH1, TH2 or TH17 lineages (2008, background): “On the other hand, sanroque mice, which have a mutation in a RING-type E3 ubiquitin ligase, Roquin, developed spontaneous autoantibody production and lupus-like autoimmunity, associated with greatly increased numbers of CXCR5+CD4+ T cells and enhanced expression of IL-21 and ICOS (Vinuesa et al., 20”
Type I interferon in systemic lupus erythematosus and other autoimmune diseases. (2006, background): “The TFh cells are expanded in two murine lupuslike models: the sanroque mice carrying a mutated ubiquitin ligase (roquin) gene (Vinuesa et al., 2005) and the B6.”
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. (2009, background): “…despite having a very distinct cell function compared to other effector T cells, they have a phenotype that is only distinguished from non-Tfh effectors by a quantitative increase in the expression of CXCR5, CXCR4, PD-1, ICOS, IL-21 and other molecules (King et al., 2008; Vinuesa et al., 2005b).”