Pathological gambling is linked to reduced activation of the mesolimbic reward system

By J. Reuter, T. Raedler, Michael Rose, I. Hand, Jan Gläscher, Christian Büchel. Nature Neuroscience, 2005

752 citations recorded by the source corpus.

Subfields: Clinical Psychology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/269d7b547795b9876a5cf1eef441c7b241d7e46d

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In Clinical Psychology

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Citations in the corpus

Triadic model of the neurobiology of motivated behavior in adolescence (2005, background): “…activity in response to aversive stimuli in monkeys (Amaral et al. 1992; Joseph et al. 2003), and the weaker response of ventral striatum to aversive stimuli relative to appetitive stimuli in human functional neuroimaging studies (Breiter et al. 2001; Knutson et al. 2001a, b ; Reuter et al. 2005).”
The genetics of addictions: uncovering the genes (2005, background): “Furthermore, the addictions encompass non-substance related behaviours that are widespread and that might access the same neurobiological pathways that modulate rewar”
Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. (2008, background): “A recent fMRI study using a monetary reward task in PG and non-gambling controls reported a blunted response in the ventral striatum in PG during monetary wins (Reuter et al., 2005).”
Introduction to Behavioral Addictions (2010, neutral): “Subjects with pathological gambling demonstrated less ventral striatal neuronal activity with fMRI while performing simulated gambling than did control subjects (52), similar to observations in alcohol-dependent subjects when processing monetary rewards (53).”
Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review (2010, background): “SAs.”
Quinte longitudinal study of gambling and problem gambling (2015, background): “One of the behavioural manifestations of this inherited propensity is a decreased sensitivity to reward (Grant, Brewer & Potenza, 2006; Oberg, Christie & Tata, 2011; Reuter et al., 2005).”
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications (2011, result): “By contrast, another study in pathological gamblers showed reduced left ventromedial PFC BOLD responses to winning versus losing in a gambling-like task, and the size of the reduction was correlated with the severity of the gambling addiction, as assessed with a gambling questionnair”
Should addictive disorders include non-substance-related conditions? (2006, background): “That is, small, immediate rewards have been found to activate preferentially brain regions implicated in PG and SUDs, including the ventral striatum and vmPFC [65,71].”
Connectivity-Based Parcellation of Human Cingulate Cortex and Its Relation to Functional Specialization (2009, neutral): “…and often using computationally derived regressors to estimate subjects’ reward expectations (Tanaka et al., 2004; Knutson and Cooper, 2005; Reuter et al., 2005; Daw and Doya, 2006; Hampton et al., 2006; Kim et al., 2006; Rolls et al., 2008) revealed the activations shown in yellow (Fig.”
Event-related potential studies of outcome processing and feedback-guided learning (2012, background): “, 2009), and pathological conditions such as compulsive gambling (Reuter et al., 2005; Goudriaan et al., 2006), drug abuse (Shiv et al.”