Genes that mediate breast cancer metastasis to lung

By Andy J. Minn, G. Gupta, P. Siegel, Paula D. Bos, Weiping Shu, D. Giri, A. Viale, Adam B. Olshen, W. Gerald, J. Massagué. Nature, 2005

3,095 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/2689d5df457ae2631e2c9cbc38dee3eb4a89fb57

How researchers see this paper

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In Molecular Biology

1. J. Massagué
2. J. Pollard
3. D. Nguyen
4. R. Weinberg
5. H. Moses
6. Larry Norton
7. Yibin Kang
8. Binzhi Qian

In Oncology

1. R. Weinberg
2. J. Massagué
3. J. Pollard
4. D. Nguyen
5. R. Noy
6. Larry Norton
7. Aleix Prat
8. Binzhi Qian

Citations in the corpus

• MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. (2010, methodology): “Tumor growth rates were analyzed by measuring tumor length (L) and width (W) and calculating the volume with the formula πLW(2)/6, as previously described (24).”
• A CXCL1 paracrine network links cancer chemoresistance and metastasis (2012, positive): “In contrast, Fascin that is part of a lung metastasis gene signature (Minn et al., 2005) did not show the same trend upon chemotherapy treatment as S100A8/9 (Figure S5E), further confirming the specificity of the association of S100A8/9 with chemotherapy resistance.”
• Cancer metastasis: building a framework. (2006, background): “cyclooxygenase 2 (COX-2) may also participate in metastatic progression (Dannenberg and Subbaramaiah, 2003; Minn et al., 2005a).”
• WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis (2009, methodology): “NSCLC cell lines were engineered to stably express a triple modality vector encoding GFP-luciferase fusion (Minn et al., 2005b).”
• Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, neutral): “More recently, a number of genes whose expression facilitates the metastatic colonization of breast cancer cells specifically to either bone (Kang et al., 2003), lung (Minn et al., 2005), brain (Bos et al., 2009), or liver (Tabariès et al., 2011) have been identified.”
• The Role of Snail in EMT and Tumorigenesis (2013, background): “A set of genes of the “lung metastasis signature” are direct or indirect targets of Snail such as ID1, SPARC or MMP2 [6,81].”
• An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer (2008, methodology): “To determine if IRDS genes are more broadly associated with resistance to RT, we analyzed 34 cancer cell lines from the NCI60 panel (8).”
• Subtypes of breast cancer show preferential site of relapse. (2008, background): “Similar findings were also reported by Minn et al. ( 8 ) who described many genes involved in the tumor cell microenvironment, which were found differentially expressed in lung metastasis in both a mouse model and primary breast tumors.”
• Tumor self-seeding by circulating cancer cells (2009, methodology): “Enhanced angiogenesis and increased recruitment of neutrophils and macrophages accompanied the seeded areas of these tumors, and seeder-derived CXCL1, which is another marker of poor prognosis in ER breast cancer (Minn et al., 2005a, 2007), was partly responsible for this recruitment.”