The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication.

By Kenneth S. Kendler, Jonathan W Kuhn, J. Vittum, C. Prescott, B. Riley. Archives of General Psychiatry, 2005

645 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/25cd1c94261c02849126892c64b2a90551c5b46a

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Citations in the corpus

Practice parameter for the assessment and treatment of children and adolescents with depressive disorders. (2007, background): “…and twin studies have shown that MDD is a familial disorder, which is caused by the interaction of genetic and environmental factors (Birmaher et al., 1996; Caspi et al., 2003; Kendler et al., 2005; Pilowsky et al., 2006; Pine et al., 1998; Reinherz et al., 2003; Weissman et al., 2005, 2006b).”
Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. (2008, background): “Moreover, the 5-HTTLPR S allele has been associated with relatively increased risk for depression in the context of environmental adversity (12-15), a relationship that may be mediated by increased neuroticism (16), a psychometrically robust index of trait negative affect.”
Strategy for investigating interactions between measured genes and measured environments. (2005, neutral): “Genotype was statistically unrelated to outcomes in the full cohorts of these studies; genotypes’ effects on disorder, apart from their role in the GxE, were virtually nil and statistically undetectable.(8-12,15,22,28,125) In these studies, genotype effects were only revealed among individuals expos”
The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-Analysis Revisited: Evidence of Genetic Moderation (2011, background): “Interestingly, 3 studies have explicitly looked at both acute and chronic stressors in their cohorts and all 3 have found that the evidence for moderating effects was stronger for chronic stressors.(13,19,48) In addition to the type of stressor studied, the stress assessment method used by investiga”
Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression (2009, background): “Chipman et al,16 2007 2095 (1089) 23 (20-24) 33 46 21 Cross sectional No List of Threatening Eventsb Depression rating scale Failed to replicate”
The evolution of the cognitive model of depression and its neurobiological correlates. (2008, background): “Also, in some studies, adverse experiences, for example, abuse in childhood (28), appear to represent a distal predisposition to depression, whereas in others, 5-HTTLPR genotype moderates the depressogenic effects of more proximal events (11).”