STAT3 signalling is required for leptin regulation of energy balance but not reproduction

By S. Bates, Walter H. Stearns, T. A. Dundon, M. Schubert, A. Tso, Yongping Wang, Alexander S. Banks, Hugh J. Lavery, Asma K. Haq, E. Maratos-Flier and 3 more. Nature, 2003

1,042 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/25ab9d73ec0d0c8fc3c6ec167cccbfe002d52c52

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. B. Kahn
2. J. Oakhill
3. S. Galic
4. G. Steinberg
5. D. Hardie
6. David M. Sabatini
7. M. Laplante
8. G. Boden

In Epidemiology

1. P. Ferré
2. G. Hotamisligil
3. J. Oakhill
4. F. Foufelle
5. S. Galic
6. G. Steinberg
7. M. Laplante
8. David M. Sabatini

In Nutrition and Dietetics

1. B. Kahn
2. D. Hardie
3. Haiming Cao

Citations in the corpus

• Leptin receptor signaling in midbrain dopamine neurons regulates feeding. (2006, neutral): “This indicates that leptin action on the VTA can also modulate behavioral responses to rewarding or novel food, consistent with proposed roles of the VTA dopamine neurons (Schultz and Dickinson, 2000) and observations of dopamine release in the NAc in response to novel food ( Bassareo and Di Chiara,”
• Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity (2004, background): “Stat3 is apparently essential for leptin regulation of energy balanc”
• The Human Obesity Gene Map: The 2005 Update (2006, background): “7) Lepr 1p31 LEPR Selective loss of long form of leptin receptor Obesity (448)”
• Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. (2015, background): “Activation JAK2-STAT3 signaling plays a crucial role in leptin's ability to regulate energy homeostasis [16, 17].”
• Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade (2018, neutral): “…on leptin as a mechanism of obesity induced T cell dysfunction given that STAT3, a major downstream transcription factor of the leptin receptor 44,45 , has known binding sites in the promoter region of PD-1 46,47 and has been implicated in driving expression of PD-1 in human and murine…”
• Obesity and Leptin Resistance: Distinguishing Cause from Effect (2010, neutral): “of genetic lesions that impair specific leptin-regulated pathways may produce selective leptin resistance, these represent a different case than DIO (39,56).”
• The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. (2003, background): “Recent evidence from transgenic animal models suggests that, in addition to the STAT3 signaling system, a distinct and parallel signal transduction pathway exists that regulates hypothalamic neuropeptide Y (NPY) and controls fertility, most likely through activation of extracellular signal-related k”
• AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus (2004, background): “Thus, our data establish a novel pathway for the regulation of food intake which, in response to leptin, most probably acts in a coordinate manner with the STAT”
• Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons (2011, neutral): “It has previously been established that leptin’s anti-obesity effects require Tyr1138 of the LEPR, which allows for phosphorylation-dependent docking and activation (via subsequent phosphorylation) of the latent transcription factor, STAT3 (Bates et al., 2003).”
• Adipose tissue as an endocrine organ. (2010, background): “Tyrosine phosphorylation of ObR-L at Tyr1138 within hypothalamic nuclei, has been found to be critical for the regulation of food intake and energy expenditure (Bates et al., 2003).”
• Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications (2010, background): “The binding of leptin to the ObRb receptor activates several signal transduction pathways, including Janus kinase signal transducer and activator of transcription 3 (JAK-STAT3), which is important for regulation of energy homeostasis (15), and phosphatidylinositol 3-kinase (PI3K), which is important”
• Neuronal PTP1B regulates body weight, adiposity and leptin action (2006, background): “Leptin-evoked activation of Stat3 suppresses expression of Agrp and stimulates expression of Pomc in the arcuate nucleus; other LRb pathways regulate Np”