P-TEFb, a Cyclin-Dependent Kinase Controlling Elongation by RNA Polymerase II

By D. Price. Molecular and Cellular Biology, 2000

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7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes (2001, background): “One element of this regulation involves phosphorylation of the carboxy-terminal domain (CTD) of the largest polymerase subunit by a transcription elongation factor, P-TEFb, which comprises the kinase CDK9 and cyclin T1 or T2 (ref”
The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription (2001, background): “jpg" NDATA ITEM> ]> The human positive transcription elongation factor P-TEFb, consisting of a CDK9/cyclin T1 heterodimer, functions as both a general and an HIV-1 Tat-specific transcription facto”
The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. (2000, background): “The mammalian CTD-kinase cdk9, a subunit of the positive transcript elongation factor (P-TEFb; Price 2000) is a potential target for a GR-recruited inhibitor.”
Elongation by RNA polymerase II: the short and long of it. (2004, background): “The elongation activity of P-TEFb is dependent on its kinase activity, and both are DRB-sensitive (Price 2000).”
RNA Polymerase II Accumulation in the Promoter-Proximal Region of the Dihydrofolate Reductase and γ-Actin Genes (2003, background): “Cyclin T-Cdk9 is a component of P-TEFb, which is responsible for Ser-2 phosphorylation and is also involved in facilitating Pol II elongation (4, 26 ).”