Cryopyrin activates the inflammasome in response to toxins and ATP

By S. Mariathasan, D. Weiss, K. Newton, J. McBride, K. O’Rourke, Merone Roose-Girma, Wyne P. Lee, Y. Weinrauch, D. Monack, V. Dixit. Nature, 2006

3,164 citations recorded by the source corpus.

Subfields: Molecular Biology, Nephrology

View Paper: https://www.semanticscholar.org/paper/2522beb6fa706c1f6e3bbd2d222e441eb3a9617a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. T. Kanneganti
2. J. Tschopp
3. G. Núñez
4. M. Lamkanfi
5. Kate Schroder
6. Shizuo Akira
7. V. Dixit
8. C. A. Dinarello

In Nephrology

1. J. Tschopp
2. Kate Schroder
3. Shizuo Akira
4. B. Sinha
5. Martin J. Fraunholz
6. G. Núñez
7. T. Kanneganti
8. E. Latz

Citations in the corpus

• Canonical Nlrp3 inflammasome links systemic low grade inflammation to functional decline in aging (2013, positive): “Nlrp3 inflammasomes can sense a wide array of DAMPs; indeed, multiple age-relevant DAMPs such as extracellular ATP, urate, ceramides, and palmitate induced IL-1b activation in macrophages in an Nlrp3-dependent manner (Figure 1A).”
• TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria (2012, positive): “We also examined a set of Gram-positive bacteria that engage the NLRP3 inflammasome (Costa et al., 2012; Fang et al., 2011; Franchi et al., 2007; Mariathasan et al., 2006).”
• Pathogen recognition and innate immunity. (2006, positive): “The ligands for NALP family members are currently unknown, except for NALP3, which is involved in the recognition of bacterial RNA, ATP, and uric-acid crystals (Kanneganti et al., 2006; Mariathasan et al., 2006; Martinon et al., 2006).”
• Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome (2010, background): “We could rule out that DSS, either directly or indirectly, induces NLRP3 inflammasome activation via the P2X7 receptor”
• Inflammasomes and their roles in health and disease. (2012, background): “Consequently, ASC is essential for assembly and activation of these PYD-containing inflammasomes (Agostini et al. 2004, Elinav et al. 2011, Kanneganti et al. 2006, Mariathasan et al. 2006, Sutterwala et al. 2006).”
• A pilot study of IL-1 inhibition by anakinra in acute gout (2007, background): “Activators of the NALP3 inflammasome include ATP, the microbial cell-wall component muramyl dipeptide and bacterial RNAs [8-10].”
• Inflammatory caspases and inflammasomes: master switches of inflammation (2007, background): “84 Other agents that decrease intracellular potassium levels such as the potassium ionophore nigericine and maitotoxin, a potent marine toxin, depend on the NALP3-based inflammasome for caspase-1 activation.(81) NALP3 and ASC are also required for caspase-1 activation by the Gram-positive bacteria S”