Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

By Ryan S. Udan, Madhuri Kango-Singh, R. Nolo, Chunyao Tao, G. Halder. Nature Cell Biology, 2003

790 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/24fc30a7a53c5b9cb9fa26fd0d144e04ad066364

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. K. Guan
2. G. Halder
3. Bin Zhao
4. Fa-Xing Yu
5. Randy L. Johnson
6. Duojia Pan
7. H. Park
8. Jung-Soon Mo

In Molecular Biology

1. K. Guan
2. Bin Zhao
3. G. Halder
4. Duojia Pan
5. Randy L. Johnson
6. Fa-Xing Yu
7. Xaralabos Varelas
8. Yonggang Zheng

Citations in the corpus

• The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. (2008, background): “Loss-of-function mutations in the hpo pathway components including hpo, sav, and wts resulted in similar tissue overgrowth phenotypes (Harvey et al., 2003; Jia et al., 2003; Pantalacci et al., 2003; Tapon et al., 2002; Udan et al., 2003; Wu et al., 2003).”
• The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. (2010, background): “sav (shar-pei) encoding a WW domain-containing protein and hippo (hpo) encoding a STE20 family protein kinase are two other Hippo pathway components identified in a similar fashion to that of wts (Kango-Singh et al. 2002; Tapon et al. 2002; Harvey et al. 2003; Jia et al. 2003; Pantalacci et al. 2003”
• The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “The Hippo pathway was identified in genetic studies of Drosophila melanogaster as a suppressor of tissue overgrowth (Huang et al., 2005; Jia et al., 2003; Justice et al., 1995; Pantalacci et al., 2003; Tapon et al., 2002; Udan et al., 2003; Wu et al., 2003).”
• TEAD mediates YAP-dependent gene induction and growth control. (2008, background): “Yki induces expression of genes like cyclin E and Diap1, and therefore promotes proliferation and inhibits apoptosis (Udan et al. 2003; Huang et al. 2005).”
• The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals (2010, background): “At the core of the Hippo signaling pathway is a kinase cascade composed of four tumor suppressor proteins, including the Ste20-like kinase Hippo (Hpo) (Wu et al., 2003; Udan et al., 2003; Harvey et al., 2003; Pantalacci et al., 2003; Jia et al., 2003) and its regulatory protein Salvador (Sav) (Tapon”
• The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment (2013, positive): “The Drosophila YAP homolog Yki is required for this response 26252724 , but unlike in mammals, Yki is activated in differentiated enterocytes which drives the expression of cytokines that then signal to stem cells and promote their proliferation 24 .”
• The Hippo Signaling Pathway in Development and Disease (2019, background): “, 2002), hippo (hpo) (Harvey et al., 2003; Jia et al., 2003; Pantalacci et al., 2003; Udan et al., 2003; Wu et al., 2003), and mob as tumor suppressor (mats) (Lai et al.”
• The Hippo signaling pathway in stem cell biology and cancer (2014, positive): “In Drosophila, the core components of the Hippo pathway include the kinase cascade of Ste20-like kinase Hpo (Hippo) and NDR family kinase Wts (Warts) [1–7].”
• Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (2007, background): “Hippo (Hpo) is a Ste20 family protein kinase that complexes with a regulatory scaffold protein Salvador (Sav) (Kango-Singh et al. 2002; Tapon et al. 2002; Harvey et al. 2003; Pantalacci et al. 2003; Udan et al. 2003; Wu et al. 2003).”
• The Hippo Signaling Pathway in Development and Cancer (2010, background): “…domain-containing protein Salvador (Sav) (Tapon et al., 2002; Kango-Singh et al., 2002), the Ste20like protein kinase Hippo (Hpo) (Wu et al., 2003; Udan et al., 2003; Harvey et al., 2003; Jia et al., 2003; Pantalacci et al., 2003) and the adaptor protein Mob-as-tumor-suppressor (Mats) (Lai et…”
• Mst1 and Mst2 maintain hepatocyte quiescence and suppress the development of hepatocellular carcinoma through inactivation of the Yap1 oncogene (2009, positive): “Loss of Hippo function (in the fly eye) results in massive overgrowth, due to an acceleration of cell cycle progression and a failure of developmental apoptosis (Harvey et al., 2003; Udan et al., 2003; Wu et al., 2003); Mst2 can complement Hippo loss of function (Wu et al., 2003).”
• Hippo signaling in organ size control. (2007, background): “…the genesis of the Hpo pathway was the identification of the Hpo tumor suppressor gene (Harvey et al. 2003; Jia et al. 2003; Pantalacci et al. 2003; Udan et al. 2003; Wu et al. 2003), which encodes a Ste-20 family protein kinase with a similar loss-of-function overgrowth phenotype to that reported…”
• Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. (2012, background): “…pathway that limits organ size under physiological conditions (Justice et al. 1995; Xu et al. 1995; Kango-Singh et al. 2002; Tapon et al. 2002; Harvey et al. 2003; Jia et al. 2003; Pantalacci et al. 2003; Udan et al. 2003; Wu et al. 2003; Huang et al. 2005; Lai et al. 2005; Dong et al. 2007).”