Prostaglandins as modulators of immunity.
By S. G. Harris, J. Padilla, L. Koumas, D. Ray, R. Phipps. Trends in immunology, 2002
1,255 citations recorded by the source corpus.
Subfields: Biochemistry, Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/24e70e0b7efba654a8a69795a8916bf9939c234d
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In Pharmacology
Citations in the corpus
- Cyclooxygenase‐2 (COX‐2) in Inflammatory and Degenerative Brain Diseases (2004, background): “However, as mentioned before, PGE2 has a broad array of functions, including potential protective effect (36).”
- CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. (2019, background): “PGE2 suppresses Teff survival and function in vitro (189) as well as in vivo during chronic LCMV infection where blockade of PGE2 synergizes with PD-1 pathway blockade (191).”
- Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut (2008, background): “In addition to the expression of immunoregulatory cytokines, IECs express a range of metabolic enzymes and intermediates, including indoleamine 2,3-dioxygenase (IDO) and cyclooxygenase-2 and its arachidonic-acid metabolite prostaglandin E 2 , which can regulate multiple innate and adaptive immune-ce”
- Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells1 (2005, background): “PGE2 has diverse effects on the regulation and activity of CD4 T cells, including modulation of proliferation (13).”
- The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. (2009, background): “In light of the known ability of PGE2 to modulate multiple aspects of the immune response [118], this additional cancer hallmark may therefore be influenced by inappropriate expression of COX-2 and PGE2 production that occurs commonly in colorectal tumours.”
- Regulation of Immune Responses by Prostaglandin E2 (2012, background): “Although PGE2 can promote the activation, maturation, and migration of dendritic cells (DCs) (see below), the central cells during the development of Ag-specific immunity, it has been widely demonstrated to suppress both innate and Ag-specific immunity at multiple molecular and cellular levels (1, 1”