The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter.

By J. Andrejeva, K. Childs, D. Young, T. Carlos, N. Stock, S. Goodbourn, R. Randall. Proceedings of the National Academy of Sciences of the United States of America, 2004

1,101 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/24d00f0c0ddd7fb0fa6c0b5727584ae37eb331af

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Shizuo Akira
2. Taro Kawai
3. Satoshi Uematsu
4. S. Ghosh
5. R. Randall
6. S. Goodbourn
7. Masahiro Yamamoto
8. Eileen M. Foy

In Immunology

1. Shizuo Akira
2. Taro Kawai
3. O. Takeuchi
4. Satoshi Uematsu
5. R. Medzhitov
6. S. Ghosh
7. M. Hayden
8. A. West

In Infectious Diseases

1. T. Fujita
2. Taro Kawai
3. Mitsutoshi Yoneyama
4. Shizuo Akira

Citations in the corpus

• Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza A Virus (2006, background): “The CARD-containing DExD/H box helicase MDA-5, a protein highly related to RIG-I, also appears to be able to sense dsRNA in a similar fashion, resulting in IFN-/ induction ( 3 ).”
• Innate immune recognition of viral infection (2006, background): “Melanoma differentiation-associated gene 5 (Mda5; also called Helicard) is structurally related to RIG-I, as it contains two CARD-like domains and a single helicase domai”
• Interferon signalling network in innate defence (2006, background): “The C-terminal domain of the V protein of most paramyxoviruses binds selectively to Mda5, thereby blocking the activation of its downstream pathway for IFN production (Andrejeva et al., 2004; Yoneyama et al., 2005) (Fig.”
• Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5 (2015, positive): “MDA5 constructs were built on the T946 variant (pEF-MDA5-c-myc plasmid [65]).”
• Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity1 (2005, background): “binding target for V proteins of paramyxoviruses (16).”
• The interferon response circuit: Induction and suppression by pathogenic viruses (2005, background): “Good examples are the V proteins of some paramyxoviruses which bind to the dsRNA-sensing helicase MDA5 and thereby block induction of IFN (Andrejeva et al., 2004) but also provoke the ubiquitinylation and subsequent degradation of STAT1 in a complex reaction (Didcock et al., 1999; Palosaari et al.,…”
• The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I1 (2005, background): “A recent report demonstrated that the V protein of several paramyxoviruses, including that of SV, binds and inactivates Mda-5 (20).”
• Viral evasion and subversion of pattern-recognition receptor signalling (2008, background): “Analogously, the V proteins of many paramyxoviruses interact with MDA5 and inhibit its function 45 , and poliovirus induces the cleavage of MDA5 by caspases 67 .”