Functional deactivations: Change with age and dementia of the Alzheimer type

By Cindy Lustig, Abraham Z. Snyder, M. Bhakta, Katherine O'Brien, M. McAvoy, Marcus E. Raichle, John C. Morris, Randy L. Buckner. Proceedings of the National Academy of Sciences of the United States of America, 2003

740 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/1bbd40639f487f665e5410c9b895466d871d53b5

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In Cognitive Neuroscience

Citations in the corpus

Linking implicit and explicit memory: common encoding factors and shared representations. (2006, background): “First, since our indoor/outdoor task was equally difficult for subsequently remembered and forgotten items (in terms of both response time and accuracy ), the observed association between deactivations and subsequent memory cannot be attributed to task difficulty per se (cf. Lustig et al., 2003).”
Frontocingulate Dysfunction in Depression: Towards Biomarkers of Treatment Response (2010, background): “…from the fact that various disease states associated with blunted resting rACC activity, including schizophrenia (Fletcher et al, 1998), dementia (Lustig et al, 2003), and autism (Kennedy et al, 2006), are characterized by reduced taskinduced rACC deactivation, although the possibility that this…”
The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques (2009, result): “…by reduced resting medial PFC activity are associated Neural Correlates of Anhedonia with reduced task-induced medial PFC deactivation (Fletcher et al., 1998; Kennedy et al., 2006; Lustig et al., 2003), and recent findings by Grimm et al. (2008) indicate that this may also apply to depression.”
When less means more: deactivations during encoding that predict subsequent memory (2004, background): “This effect may reflect the recruitment of a compensatory mechanism, and it is unclear how it relates to reduced activations in elderly and AD patients (Lustig et al., 2003). revDMs due to activations for F-items (aFs) In addition to areas showing dRs, we also identified regions showing aFs.”
Age-related Changes in Brain Activity across the Adult Lifespan (2006, background): “…8 M a y 2 0 2 1 D ow nloaded from http://direct.m it.edu/jocn/article-pdf/18/2/227/1935728/jocn.2006.18.2.227.pdf by guest on 12 O ctober 2021 studied the default mode (Greicius et al., 2004; Lustig et al., 2003), indicate that this approach overlooks some valuable information about brain function.”
Mapping the Structural Core of Human Cerebral Cortex (2008, background): “associated with the onset of Alzheimer-type dementia [42,43].”
Network Analysis of Intrinsic Functional Brain Connectivity in Alzheimer's Disease (2008, background): “Three recent studies have reported reduced default-mode network deactivation in MCI and/ or AD patients during encoding tasks [12,13] and during a semantic classification task [14].”
Alterations in Memory Networks in Mild Cognitive Impairment and Alzheimer's Disease: An Independent Component Analysis (2006, background): “…network was related to increased expression of positive activity in these same parietal regions, consistent with the theory that loss of ability to regulate or functionally inhibit activation may underlie the failure of deactivation or default mode activity in MCI and AD (Lustig et al., 2003).”
Reduced resting-state brain activity in the "default network" in normal aging. (2008, background): “…parietal and decreased hippocampal activation (Cabeza et al. 2004; Daselaar et al. 2006), increased (Sharp et al. 2006) and also decreased (Otsuka et al. 2006) anterior cingulate cortex activation, and decreased deactivation of the medial parietal/posterior cingulate region (Lustig et al. 2003).”
Unrest at rest: Default activity and spontaneous network correlations (2007, background): “Several studies have demonstrated that clinical diagnosis of Alzheimer’s disease correlates with differences in default network activity (e.g., Lustig et al., 2003; Greicius et al., 2004; Rombouts et al., 2005; Wang et al., 2006).”
A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume (2004, neutral): “Group-based functional imaging studies often use, or begin with, affine transformation to an atlas target (e.g., Bäckman et al., 1999; Bookheimer et al., 2000; Cabeza et al., 1997; Grady et al., 1995; Logan et al., 2002; Lustig et al., 2003; Madden et al., 1999).”
Que PASA? The posterior-anterior shift in aging. (2008, background): “in several populations including Alzheimer’s (Lustig et al. 2003), amnesia (Maguire et al.”
Plasticity of Brain Networks in a Randomized Intervention Trial of Exercise Training in Older Adults (2010, neutral): “…measures were collected as part of a larger task battery, and were originally developed to be passive viewing tasks for localizing stimulus-specific processing regions of the ventral visual cortex. et al., 2009) and positive diagnosis of MCI and AD (Lustig et al., 2003; Greicius et al., 2004).”
Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer’s Disease (2009, background): “, 2005), and disruption of activity (Lustig et al., 2003; Greicius et al., 2004) and metabolism (Herholz, 1995; Minoshima et al.”