Plasma membrane monoamine transporters: structure, regulation and function

By G. Torres, R. Gainetdinov, M. Caron. Nature Reviews Neuroscience, 2003

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Recent advances in ligand-based drug design: relevance and utility of the conformationally sampled pharmacophore approach. (2011, background): “Depending on the nature of the disease state, molecules, referred to as lead compounds, are identified or designed to inhibit or promote the concerned biochemical pathway [15-18].”
Identification of an allosteric modulator of the serotonin transporter with novel mechanism of action. (2013, background): “…Naþ/Cl -dependent carrier family, the serotonin transporter (SERT) is expressed on the plasmamembrane, where it catalyzes the uptake of serotonin (Torres et al., 2003; allosteric transporter modu, extracellular loop; FBS, fetal HSB, hybrid structure based; molecular dynamics; MDMA, T,…”
Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells (2015, background): “Interestingly, both Slc6a4 and Htr4 are expressed by intestinal epithelial cells and other cell types (9, 36).”