Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
By R. H. Green, C. Brightling, G. Woltmann, D. Parker, A. Wardlaw, I. Pavord. Thorax, 2002
882 citations recorded by the source corpus.
Subfields: Physiology, Pulmonary and Respiratory Medicine, Sociology and Political Science
View Paper: https://www.semanticscholar.org/paper/241fa835db910fbc1a3c4647027e75502607aa92
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Citations in the corpus
- A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. (2007, background): “Although inhaled corticosteroid therapy reduces airway eosinophilia, approximately 50% of patients with severe asthma nevertheless experience persistent eosinophilic airway inflammation (11, 12 ).”
- Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma (2007, neutral): “CHARACTERISTICS OF CLINICAL ASTHMA.........................................................12 FIGURE 2–1.”
- The Microbiome and the Respiratory Tract (2015, result): “Compared with patients with eosinophilic asthma, patients with noneosinophilic asthma have more frequent severe exacerbations and respond more poorly to corticosteroids (84).”
- Immunology of asthma and chronic obstructive pulmonary disease (2008, background): “Interestingly, the presence of eosinophils seems to be a good marker of steroid responsivenes”
- IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? (2006, background): “The subgroup of patients with neutrophilic asthma is characterized by poor response to corticosteroids [21].”
- An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. (2009, result): “Symptom scores in adults and children generally have moderate or weak correlations with other asthma outcomes, including static lung function, PEF variability, airway reactivity, and airway inflammation (69, 70, 123, 135), consistent with the fact that these represent different domains of asthma con”