Physiology of local renin-angiotensin systems.

By M. Paul, Ali Poyan Mehr, R. Kreutz. Physiological Reviews, 2006

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan (2016, positive): “Angiotensin receptor blockers attenuate age-related glomerulosclerosis under normotensive conditions, which has led to the idea that overactivation of the local renin-angiotensin-aldosterone system (RAAS) drives the formation of sclerotic glomeruli 31, 32 .”
Biological activity of peptides purified from fish skin hydrolysates (2019, positive): “Renin in circulation catalyzes the conversion of angiotensinogen to angiotensin I which is then subsequently converted to angiotensin II by the enzyme angiotensin-converting enzyme (ACE) (Paul 2006).”
Role of the ACE2/Angiotensin 1–7 axis of the Renin-Angiotensin System in Heart Failure (2016, background): “cells), or endocrine effects (on a distant organ or tissue; via systemic circulation).(6,14) Our conception of the RAS family has seen substan-”
The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease (2007, background): “There has also been a growing appreciation of the organ-specific roles exerted by Ang II acting as a paracrine factor (Navar et al., 1996; Paul et al., 2006).”