Apoptotic pathways: paper wraps stone blunts scissors.

By Douglas R. Green. Cell, 2000

1,076 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/235edb0f1c7622071e4d10a175ca4547143bd281

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Subash C. Gupta
2. J. Kim
3. Heidi N. Leblanc
4. W. Zong
5. S. Prasad
6. Bharat B. Aggarwal
7. Howard Y. Chang
8. Scott W. Lowe

In Immunology

1. Bharat B. Aggarwal
2. Subash C. Gupta
3. W. El-Deiry
4. Ricky W. Johnstone
5. Heidi N. Leblanc
6. W. Zong
7. A. Ma
8. Howard Y. Chang

In Molecular Biology

1. A. Strasser
2. Bharat B. Aggarwal
3. Jerry M. Adams
4. Scott W. Lowe
5. Subash C. Gupta
6. S. Prasad
7. Ricky W. Johnstone
8. J. Kim

Citations in the corpus

• Apo2L/TRAIL and its death and decoy receptors (2003, background): “mitochondrial transmembrane potential dissipates, and cytochrome c is released to the cytosol, activating caspase-9 and subsequently the effector caspases.(33) Proapoptotic members of the Bcl-2 family such as Bax or its homologue Bak are counteracted by the antiapoptotic family members Bcl-2 or Bcl-”
• The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. (2000, background): “Two major apoptotic pathways have been identified (Strasser et al., 1995; Green, 2000).”
• The expanding role of mitochondria in apoptosis. (2001, background): “The regulation provided by the Smac and IAPs interaction may not be limited to the cytochrome c pathway (Green 2000; Srinivasula et al. 2000).”
• Apoptosis A Link between Cancer Genetics and Chemotherapy (2002, background): “For example, caspase-8 canacterized (Green, 2000; Wang, 2001) (Figure 2).”
• Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals (2010, background): “Homeostasis is carried out in a genetically programmed manner by a process referred to as apoptosis (programmed cell death) [53-55].”
• Molecular mechanisms of cell death in neurological diseases (2021, background): “Apoptosis can be triggered by two distinct pathways: the intrinsic (also called mitochondrial or BCL-2-regulated) pathway and the death receptor (also called extrinsic) pathways [20, 21].”
• Acetylation of the p53 DNA-binding domain regulates apoptosis induction. (2006, background): “These events lead to the activation of caspases and ultimately apoptotic cell death (Green, 2000).”
• Anoikis: an emerging hallmark in health and diseases (2012, background): “Caspase-8 can now independently activate effector caspases (type I extrinsic anoikis) or cleave the BH3-only protein Bid (type II extrinsic anoikis) (Figure 1) [7].”