Protein aggregation and neurodegenerative disease

By Christopher A. Ross, Michelle A. Poirier. Nature Medicine, 2004

3,378 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/22c94ab0c86601aabe73f1628f33ee69bd3d64d1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Maiken Nedergaard
2. V. Lee
3. John Q. Trojanowski
4. Jeffrey J. Iliff
5. F. Hartl
6. R. Deane
7. Minghuan Wang
8. C. Iadecola

In Molecular Biology

1. Jimin Pei
2. Nick V. Grishin
3. John Q. Trojanowski
4. G. Jayaraj
5. C. L. Klaips
6. M. Grimaldo
7. F. Roosen‐Runge
8. F. Hartl

In Physiology

1. V. Lee
2. John Q. Trojanowski
3. F. Hartl
4. S. McKnight
5. R. Deane
6. P. Shaw
7. S. Barber
8. Maiken Nedergaard

Citations in the corpus

• Lysosomes as a therapeutic target (2019, background): “NATure revIewS | Drug DiSCOvErY each disease [153] [154] [155] .”
• Secondary Structure of α-Synuclein Oligomers: Characterization by Raman and Atomic Force Microscopy (2006, background): “Neuronal loss and accumulation of intracellular or extracellular protein aggregates are common characteristics of a wide variety of neurodegenerative diseases.(1) On the basis of several observations, a-synuclein aggregation is thought to have an important role in Parkinson’s disease (PD): (1) a-syn”
• Pathways of cellular proteostasis in aging and disease (2018, background): “Such amyloid aggregates form insoluble deposits and are the hallmark of several age-dependent proteinopathies, including Alzheimer’s, Parkinson’s, and Huntington’s diseases (Ross and Poirier, 2004).”
• Cell-Free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers Within Hydrogels (2012, background): “Ample evidence has accumulated showing that LC sequences can form pathological aggregates, particularly in the context of neurodegenerative disease (Ross and Poirier, 2004; Shastry, 2003).”
• Oxidative stress in ALS: key role in motor neuron injury and therapeutic target. (2010, background): “…aggregates is a common pathological feature of many neurodegenerative diseases, including ALS, although whether they play a role in disease pathogenesis, are harmless byproducts , or represent a defense mechanism by sequestration of harmful intracellular proteins is not known [137] [138] [139].”
• Impairment of paravascular clearance pathways in the aging brain (2014, background): “A central histopathological hallmark of each of these diseases is the presence of misaggregated proteins, including senile plaques comprised of amyloid-b (Ab) in AD, neurofibrillary tangles comprised of hyperphosphorylated tau in AD and CTE, Pick bodies comprised of hyperphosphorylated tau in fronto”
• Cellular strategies for controlling protein aggregation (2010, background): “Such mutations are responsible for various 'conformational diseases', such as type II diabetes, Huntington's disease and familial forms (which are inherited and have a higher probability of developing in the affected family) of Parkinson's disease and Alzheimer's diseas”