New insights into TGF-β–Smad signalling

By P. ten Dijke, C. Hill. 2004

1,170 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/22aae5e7d1060d2b933bc35aaf9f478acd333ed0

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In Molecular Biology

Citations in the corpus

Transforming Growth Factor (TGF)-β signaling in cardiac remodeling (2010, background): “TGF-β transduces its signal th ALK1 as well as the bone morphogenetic protein (BMP) receptors [14].”
The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. (2007, background): “It has profound effects on VIC differentiation,(62,63) increasing the expression of -SMA, smooth muscle myosin, and calponin.(64) On the cell surface, TGF- binds to TGF- receptor type I and II leading to signaling through the Smad proteins, which interact with transcription factors including FoxH1, ”
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells (2005, background): “…SB431542, which has been shown to specifically inhibit the receptors responsible for both Activin/Nodal (Alk4, Alk7) and TGF 1 (Alk5) signalling through Smad2/3 in the majority of cell types studied to date (Inman et al., 2002; James et al., 2005; Piek et al., 1999; ten Dijke and Hill, 2004).”
The nuclear lamina comes of age (2005, background): “, which mediate signalling downstream of bone morphogenetic proteins (BMPs) and other members of the TGFβ superfamil”
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. (2005, background): “These observations suggest that both TGF-b 1 and BMP-4 increase hepcidin expression by directly activating SMAD4 protein, which is consistent with the direct activation of SMAD4 by TGF-b signaling demonstrated previously (reviewed by Hel-din et al., 1997; Massague, 1998; ten Dijke and Hill, 2004).”
TGF-β signaling in fibrosis (2011, background): “The R-Smads, Smad2, and Smad3 are phosphorylated directly by ALK5, whereas Smad1, Smad5, and Smad8 are activated by ALK1 (ten Dijke and Hill 2004).”
Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “TGF- is the prototypic member of a superfamily of secreted proteins, whose other members include the Bone Morphogenic Proteins (BMPs) and Activins (for review, see ten Dijke and Hill 2004).”