Increased baseline occupancy of D2 receptors by dopamine in schizophrenia.

By Anissa Abi-Dargham, J. Rodenhiser, D. Printz, Y. Zea‐Ponce, R. Gil, L. Kegeles, R. Weiss, T. Cooper, J. Mann, R. Heertum and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2000

1,093 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/07bd6b7c8c693874066195639e8bdcf9e88f1b40

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Citations in the corpus

Glutamate and dopamine in schizophrenia: an update for the 21st century (2015, result): “This is in agreement with earlier findings that found increased synaptic dopamine was predictive of treatment response (Abi-Dargham et al., 2000).”
The dopamine hypothesis of schizophrenia: version III--the final common pathway. (2009, positive): “Evidence in line with this comes from a SPECT study using a dopamine depletion technique that found that baseline occupancy of D2 receptors by dopamine is also increased in schizophrenia.(33)”
Dysfunction of ventral striatal reward prediction in schizophrenia (2006, result): “However, in the present study, schizophrenics were unmedicated, and, in prior studies, neuroleptic-free schizophrenics displayed increased, rather than decreased, presynaptic dopamine uptake capacity (Hietala et al., 1999; Lindstrom et al., 1999) and dopamine release (Abi-Dargham et al., 2000).”
Elevated striatal dopamine function linked to prodromal signs of schizophrenia. (2009, positive): “Moreover, the magnitude is directly related to the severity of amphetamine-induced psychotic symptoms and the response to subsequent antipsychotic treatment.(4,5) Further studies(7-13) have investigated presynaptic striatal dopaminergic function using the PET radiotracers carbon 11–L-dopa and 6-[(18”
Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring (2009, background): “treatment by D2 antagonists: patients with high levels of D2 receptor occupancy responded much more rapidly to treatment than patients with normal levels of D2 receptor occupancy.(202) Based on these (and other) findings, Laruelle et al(85) hypothesized that in the former group of schizophrenic pati”