Contributions of Antibiotic Penetration, Oxygen Limitation, and Low Metabolic Activity to Tolerance of Pseudomonas aeruginosa Biofilms to Ciprofloxacin and Tobramycin

By Marshall C Walters, F. Roe, Amandine Bugnicourt, M. Franklin, P. Stewart. Antimicrobial Agents and Chemotherapy, 2003

983 citations recorded by the source corpus.

Subfields: Microbiology, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/225681ecc5d7dedf0db6f2739fd0366d8fa11152

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Microbiology

1. James J. Collins
2. P. Stewart
3. R. Vasudevan

In Molecular Biology

1. T. Bjarnsholt
2. James J. Collins
3. R. Vasudevan
4. S. Ha
5. I. Jahid
6. P. Stewart
7. T. Mah
8. G. O’Toole

In Molecular Medicine

1. James J. Collins
2. G. O’Toole
3. P. Stewart
4. M. Franklin
5. T. Bjarnsholt
6. P. Watnick
7. S. Ha
8. C. Beloin

Citations in the corpus

• Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms (2009, background): “Studies using microelectrodes have shown that oxygen penetration into the biofilm core decreases with increasing biofilm thickness due to consumption of oxygen by the biofilm-based bacteria closest to the environmental interface (10, 340).”
• Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era (2013, background): “…interactions and DNA exchange (Flemming and Wingender 2010; Koo et al. 2010), while protecting the biomass from desiccation, predation, oxidizing molecules, radiation, and other damaging agents (Walters et al. 2003; Jefferson et al. 2005; Mai-Prochnow et al. 2008; Flemming and Wingender 2010).”
• Surviving as a community: antibiotic tolerance and persistence in bacterial biofilms (2019, background): “Cells buried inside thick biofilms could be in stationary phase, as penetration of nutrients and oxygen are known to be limited due to consumption by peripherally-located cells (Walters et al., 2003).”
• Bacterial Extracellular Polysaccharides in Biofilm Formation and Function (2015, background): “However, studies have demonstrated that several antibiotics can readily penetrate the bio fi lm (83, 84).”
• Antibiotic resistance of bacterial biofilms. (2010, neutral): “of biofilms to aminoglycosides and ciprofloxacin (69).”
• Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics (2014, background): “aeruginosa biofilms reduce tobramycin and ciprofloxacin bactericidal effects (42).”
• Physiological heterogeneity in biofilms (2008, methodology): “Another strategy for visualizing patterns of protein synthetic activity is to use an inducible GFP construc”
• Polymicrobial Interactions: Impact on Pathogenesis and Human Disease (2012, background): “Such microcommunities are highly recalcitrant to antibiotic therapy (200, 216).”
• Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action (2017, background): “interface, the part of the biofilm exposed to oxygen (50– 90 mm in the biofilm).(24) Moreover, studies also demon-”