Surviving as a community: antibiotic tolerance and persistence in bacterial biofilms
By Jing Yan, B. Bassler. Cell Host and Microbe, 2019
637 citations recorded by the source corpus.
Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, in medicine, and in industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development.
Subfields: Ecology, Endocrinology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/9c2d298a3563014733c90b4b5bfa7a2788fa45ce
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In Endocrinology
In Molecular Biology
Citations in the corpus
- Antimicrobial Resistance in ESKAPE Pathogens (2020, background): “Upon treatment cessation, these persistent subpopulations are then able to resume growth, thus contributing to relapsing or chronic infection (252, 255, 256).”