Identification of the platelet ADP receptor targeted by antithrombotic drugs
By Gunther Hollopeter, H. Jantzen, Diana Vincent, Georgia Li, Laura England, V. Ramakrishnan, Ruey‐Bing Yang, P. Nurden, A. Nurden, D. Julius and 1 more. Nature, 2001
1,498 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Hematology, Physiology
View Paper: https://www.semanticscholar.org/paper/2237151b132282a02c6de4840204924eab308193
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cardiology and Cardiovascular Medicine
In Physiology
- G. Burnstock
- Maria P. Abbracchio
- D. Julius
- G. Knight
- W. Junger
- H. Zimmermann
- Clifford J. Woolf
- Guo-Yuan Yang
Citations in the corpus
- Pathophysiology and Therapeutic Potential of Purinergic Signaling (2006, background): “Platelets are known to express P2Y 1 , P2Y 12 , and P2X 1 receptors (Hollopeter et al., 2001).”
- International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy (2006, background): “The long-awaited Gi-coupled ADP receptor (P2Y12) of platelets was finally isolated by expression cloning (Hollopeter et al., 2001), and P2Y13 and P2Y14 receptors were characterized during a systematic study of orphan receptors (Chambers et al.”
- Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. (2009, background): “sion of clopidogrel to its active metabolite.(4,5,17,18,32-35) A guanine adenine mutation in exon 5 of CYP2C19 ( r s4244285 , a l so known as CYP2C19*2) creates an aberrant splice site that leads to an altered reading frame at amino acid 215 and a premature stop codon 20 amino acids downstream, prod”
- The P2Y12 receptor regulates microglial activation by extracellular nucleotides (2006, background): “Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.”
- Cellular distribution and functions of P2 receptor subtypes in different systems. (2004, background): “The P2Y12 receptor found on platelets was not cloned until more recently (Hollopeter et al., 2001), although it has only 19% homology with the other P2Y receptor subtypes.”