Cellular distribution and functions of P2 receptor subtypes in different systems.

By G. Burnstock, G. Knight. International Review of Cytology, 2004

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Pathophysiology and Therapeutic Potential of Purinergic Signaling (2006, background): “eral and central nervous systems and that purines are also powerful extracellular messengers to non-neuronal cells, including exocrine and endocrine, secretory, endothelial, musculoskeletal, immune, and inflammatory cells (Burnstock and Knight, 2004).”
Neuronal calcium signaling: function and dysfunction (2014, background): “These subunits are widely distributed pre-and postsynaptically in different cell types in the brain and spinal cord [33].”
Purinergic signalling and disorders of the central nervous system (2008, background): “Multiple purinergic receptors have also been identified on glial cells, including astrocytes, oligodendrocytes and microgli”
The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance (2006, positive): “There are multiple P2X and P2Y receptor subtypes expressed by monocytes and dendritic cells, whereas lymphocytes express only P2Y receptors [2].”
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy (2006, background): “(For references, see Burnstock and Knight, 2004.)”
The P2X7 Receptor: A Key Player in IL-1 Processing and Release1 (2006, background): “P2YRs are G protein coupled, whereas P2XRs are cation-selective channels (31, 32).”