Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing.

By N. W. Kam, Zhuang Liu, Hongjie Dai. Journal of the American Chemical Society, 2005

745 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2213c63d1b4505ceffcbb9bc24bc5b383b809ac1

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Citations in the corpus

Cancer nanomedicine: a review of recent success in drug delivery (2017, background): “These SWCNTs also bind to attached molecules via cleavable disulfide bonds, allowing for drug materials to be removed from the SWCNTs in the presence of certain enzymes [57].”
FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents (2006, neutral): “This resembled PL-PEG functionalization of carbon nanotube”
Treating metastatic cancer with nanotechnology (2011, background): “Other nanomaterial classes, such as iron nanoparticles and carbon nanotubes or spheres (buckyballs), have been used to deliver therapies, often by binding the drug to the outer surface or by filling the interior, where applicabl”
Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. (2007, result): “The imaging of f -CNTs and not their adsorbed macromolecules, as previously reported by other group”
Reduction-sensitive polymers and bioconjugates for biomedical applications. (2009, background): “Dai and coworkers conjugated various biological molecules, including oligonucleotides and siRNA, to phospholipid–PEG functionalized single-walled carbon nanotube (SWNT) via cleavable disulfide linkage (Scheme 13) [104].”
Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery (2009, background): “including biological sensing, imaging and drug delivery in vitro with cells or in vivo with animals [18, 20, 24, 35, 37, 44, 45, 51].”
Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy (2008, methodology): “2-mM solution of PL-PEG for 1 h followed by centrifugation at 24,000 g for 6 h, yielding a suspension of SWNTs with noncovalent PL-PEG coating in the supernatant (15, 20, 40).”
Drug delivery with carbon nanotubes for in vivo cancer treatment (2008, background): “cells, including drugs (7–9), peptide (10), proteins (11), plasmid DNA (12), and small interfering RNA (13, 14), via endocytosis (15).”