Drug delivery with carbon nanotubes for in vivo cancer treatment
By Zhuang Liu, Kai Chen, C. Davis, S. Sherlock, Qizhen Cao, Xiaoyuan Chen, Hongjie Dai. Cancer Research, 2008
2,066 citations recorded by the source corpus.
Chemically functionalized single-walled carbon nanotubes (SWNTs) have shown promise in tumor targeted accumulation in mice and exhibit biocompatibility, excretion and little toxicity. Here, we demonstrate in-vivo SWNT drug delivery for tumor suppression in mice. We conjugate paclitaxel (PTX), a widely used cancer chemotherapy drug to branched polyethylene-glycol (PEG) chains on SWNTs via a cleavable ester bond to obtain a water soluble SWNT-paclitaxel conjugate (SWNT-PTX). SWNT-PTX affords higher efficacy in suppressing tumor growth than clinical Taxol® in a murine 4T1 breast-cancer model, owing to prolonged blood circulation and 10-fold higher tumor PTX uptake by SWNT delivery likely through enhanced permeability and retention (EPR). Drug molecules carried into the reticuloendothelial system are released from SWNTs and excreted via biliary pathway without causing obvious toxic effects to normal organs. Thus, nanotube drug delivery is promising for high treatment efficacy and minimum side effects for future cancer therapy with low drug doses.
Subfields: Biomedical Engineering, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/d2c2ca43e736ce6113ee507f9a2217ae57c0580c
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In Biomedical Engineering
In Materials Chemistry
Citations in the corpus
- Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery (2009, methodology): “including biological sensing, imaging and drug delivery in vitro with cells or in vivo with animals [18, 20, 24, 35, 37, 44, 45, 51].”
- Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. (2009, background): “While the present paper was in preparation, a report appeared describing nontargeted delivery of paclitaxel on SWNTs in mice.(31) Herein, we provide the first demonstration that targeted SWNT drug delivery results in rapid decrease of tumor size in mice compared to a nontargeted SWNT control.”
- Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant (2013, background): “Studies of a paclitaxel-nanotube construct demonstrated superior ity to Taxol via increased plasma half-life, increased tumor accumulation via EPR, and improved response to therapy in a murine breast cancer model [51].”
- The Toxic Effects and Mechanisms of CuO and ZnO Nanoparticles (2012, methodology): “Nanomaterials have also been used for various fundamental and practical applications, such as drug delivery, cell imaging, and cancer therapy [8–12].”
- In vivo pharmacokinetics, long-term biodistribution, and toxicology of PEGylated graphene in mice. (2011, background): “Similar black spots or pigments were observed before in the liver of mice injected with carbon nanotubes.(6,34) We counted the total numbers of black spots over large image fields and plotted the averaged spot numbers per field against the time (Figure 2f).”