Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway.

By Sreyashi Basu, R. Binder, R. Suto, K. M. Anderson, P. Srivastava. International Immunology, 2000

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HMGB1 is an endogenous immune adjuvant released by necrotic cells (2004, background): “Candidates include heat-shock proteins (Basu et al, 2000) and uric acid (Shi et al, 2003); significantly, uric acid can derive from the breakdown of adenosine triphosphate (ATP)—itself a cell component released by necrotic cells—by phosphodiesterases and other enzymes, such as xanthine oxidase that…”
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells (2011, background): “Among these molecules are heat-shock proteins (Basu et al., 2000), uric acid (Shi et al.”
CD91: a receptor for heat shock protein gp96 (2000, background): “HSPs such as gp96 are obligate intracellular molecules and are released into the extracellular milieu solely under conditions of necrotic but not apoptotic cell deat”
Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. (2006, background): “Immature dendritic cells efficiently phagocytose a variety of apoptotic and necrotic tumour cells, but only the latter induce maturation and optimal presentation of tumour antigens [195,196].”
How dying cells alert the immune system to danger (2008, background): “Moreover, purified HSPs have been shown to stimulate DCs to mature ex vivo”