Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex.

By K. Mirnics, F. Middleton, A. Márquez, D. Lewis, Pat Levitt. Neuron, 2000

896 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/21c444f7233d79f5c3041fb4d3fcda36d1b2ddfa

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Citations in the corpus

The Human Brain Revisited: Opportunities and Challenges in Postmortem Studies of Psychiatric Disorders (2002, background): “For example, expression of the mRNA for N-ethylmaleimide sensitive factor was consistently decreased in the prefrontal cortex of subjects with schizophrenia, independent of whether they had history of alcoholism (Mirnics et al. 2000).”
Integrating diverse genomic data using gene sets (2011, methodology): “Many current gene set analysis methods proceed in two stages [4,36-38]: gene-level testing of differences between groups and set-level testing of differences in scores.”
Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia (2003, methodology): “…to general deterioration of mRNA integrity in subjects with schizophrenia because the expression of CR mRNA, and of a large number of other transcripts (at least in subject pairs 1–10) (Glantz et al., 2000; Mirnics et al., 2000; Middleton et al., 2002), did not differ between the subject groups.”
The synapsins: key actors of synapse function and plasticity. (2010, result): “microarray analysis (Mirnics et al., 2000), although other studies did not confirm these results (Imai et al.”
Synaptic plasticity and dysconnection in schizophrenia. (2006, background): “However, given the polygenetic nature of schizophrenia and evidence from gene expression studies (Mirnics et al 2000), it is likely that mechanisms of abnormal modulation of plasticity differ across patients.”
AAA+ proteins: have engine, will work (2005, background): “, and between decreased levels of NSF and schizophrenia and epileps”
Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring (2009, background): “of gene expression.(187) The final and perhaps most important conclusion is that, although patients may differ in their genetic risk profile, the resulting pathophysiological processes ultimately leading to schizophrenia may nevertheless converge onto the same functional pathway.”
Analysing biological pathways in genome-wide association studies (2010, background): “Future directions and extensions Pathway approaches for expression microarray data were first proposed almost a decade ag”
Evolution of the neocortex: Perspective from developmental biology (2009, neutral): “, or on comparisons between diseased and healthy brain”
A Research Agenda For DSM-V (2002, background): “1999), and genes associated with neurotransmitter release (Mirnics et al. 2000).”