Synaptic plasticity and dysconnection in schizophrenia.

By Klaas E. Stephan, Torsten Baldeweg, Karl J. Friston. Biological Psychiatry, 2006

847 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/ac7ec2c8b994ab2eb9f8e46d88878088f746c2a7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Karl J. Friston
2. Klaas E. Stephan
3. Torsten Baldeweg
4. Jean Daunizeau
5. E. T. Rolls
6. H. D. den Ouden
7. Morten L. Kringelbach
8. Gustavo Deco

In Cognitive Neuroscience

1. Karl J. Friston
2. Olaf Sporns
3. D. Bassett
4. Morten L. Kringelbach
5. Stephen M. Smith
6. Gustavo Deco
7. E. Bullmore
8. Michael Breakspear

Citations in the corpus

• Great Expectations: Using Whole-Brain Computational Connectomics for Understanding Neuropsychiatric Disorders (2014, background): “The networks underlying anhedonia, the lack of pleasure, are compromised in the diseased brain (Treadway and Zald, 2011) and, specifically, disruptions have been demonstrated to the predictive coding underlying reinforcement learning (Stephan et al., 2006).”
• Computational models of schizophrenia and dopamine modulation in the prefrontal cortex (2008, background): “Furthermore, reduced connectivity can lead to parts of a network operating as separate attractor networks 56,57 , and this provides a model of the disconnection hypothesis of schizophrenia , in which, for example, the frontal and temporal lobes become relatively disconnected 58,59 .”
• ERP Repetition Effects and Mismatch Negativity Generation A Predictive Coding Perspective (2007, methodology): “We have argued elsewhere (Stephan et al., 2006) for the utility of MMN in investigating the neuromodulatory effects on synaptic plasticity during human perceptual learning.”
• Behavioral / Systems / Cognitive Striatal Prediction Error Modulates Cortical Coupling (2010, positive): “Ultimately, this approach may help to establish neurophysiologically grounded diagnostic classifications of spectrum diseases, such as schizophrenia (Stephan et al., 2006).”
• Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia. (2007, background): “Current theories of schizophrenia highlight the potential role of altered brain connectivity that may be manifest at a macro-anatomical level through structural changes of white matter tracts (Stephan et al., 2006).”
• Altered Resting State Complexity in Schizophrenia (2011, background): “, 2011) such as synaptic plasticity or developmental wiring (Stephan et al., 2006).”
• The mismatch negativity: A review of underlying mechanisms (2009, background): “Two features make the MMN a particularly interesting paradigm for schizophrenia research (see Stephan et al., 2006, for a review).”
• Bayesian Model Selection for Group Studies (2009, neutral): “schizophrenia, patients with identical symptoms show heterogeneity with regard to the pathophysiological processes involved (Stephan et al., 2006).”
• Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring (2009, background): “Collectively, the experimental evidence summarized above indicates that schizophrenia is a spectrum disease that may be caused by different genetic mechanisms and pathophysiological processes; these processes, however, appear to converge onto the same functional pathway, ie, the regulation of NMDAR-”
• Meta-analysis of diffusion tensor imaging studies in schizophrenia. (2009, background): “Such abnormalities in functional connectivity could be due to abnormalities of axonal connectivity between regions (Bullmore et al., 1997), or they could be attributed to abnormal synapse formation and plasticity (Stephan et al., 2006).”
• Schizophrenia, neuroimaging and connectomics (2012, background): “…of hypo-connectivity (Alexander-Bloch et al., 2010; Fornito et al., 2011c; Lynall et al., 2010), hyper-connectivity (Salvador et al., 2007; Whitfield-Gabrieli et al., 2009), and a more generalized dysconnectivity syndrome involving both (Liu et al., 2008; Stephan et al., 2006; Wolf et al., 2009).”
• The Computational Anatomy of Psychosis (2013, background): “NMDA-Rs play a central role in theories of schizophrenia (Olney and Farber, 1995; Abi-Saab et al., 1998; Goff and Coyle, 2001; Stephan et al., 2006; Corlett et al., 2011).”