Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of…

By V. Navarro, J. Castellano, R. Fernández-Fernández, M. Barreiro, J. Roa, J. Sánchez-Criado, E. Aguilar, C. Diéguez, L. Pinilla, M. Tena-Sempere. Endocrinology, 2004

720 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Reproductive Medicine, Social Psychology

View Paper: https://www.semanticscholar.org/paper/21ade6dd5fa538a75db7c679c00ff5e41256808c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

In Reproductive Medicine

Citations in the corpus

Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone (GnRH) neurons (2006, background): “Importantly, whole hypothalamic levels of both kisspeptin and GPR54 mRNA are known to increase across postnatal development (9, 23), suggesting that kisspeptin-GPR54 signaling in the hypothalamus is up-regulated around the time of puberty.”
Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity (2017, background): “…that kisspeptin neurons might be involved in the negative feedback regulation by gonadal steroids were seen in gonadectomized rats, where removal of the gonads significantly increased KiSS 1 mRNA levels, and this effect was reversed by replacement with gonadal steroids (Navarro et al., 2004).”
Advances in male contraception. (2008, background): “Testosterone clearly inhibits kisspeptin transcription (67) and GnRH and gonadotropin secretion (71–74).”
Kisspeptins and reproduction: physiological roles and regulatory mechanisms. (2012, methodology): “Furthermore, the fact that kisspeptins appear astonishingly potent via different routes of administration, both centrally [intracerebroventricular (icv) and intrahypothalamic] and systemically [intravenous (iv), intraperitoneal (ip), and subcutaneous (sc)] (268, 298, 300, 333, 336, 476), further emp”
Regulation of Kiss1 gene expression in the brain of the female mouse. (2005, result): “These results are consonant with an earlier report on studies in the female rat in which it was demonstrated, based on gross dissections of the diencephalon, that treatment of OVX animals with E2 reduces total hypothalamic content of KiSS-1 mRNA (24).”
Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. (2007, background): “have now been identified in mice (21, 22), rats (6, 20), ham-”
Kisspeptin signaling in the brain. (2009, neutral): “, with testosterone, estradiol, or dihydrotestosterone) (76, 80, 100, 105, 143).”
Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. (2005, background): “Furthermore, male mice lacking ER show no significant reproductive abnormalities (36), and treatment of castrated rats with a selective ER ligand has no effect on LH concentration or hypothalamic KiSS-1 mRNA expression (32).”
Metabolism Disrupting Chemicals and Metabolic Disorders (2016, positive): “function of the kisspeptin-Kiss1R system is sex-specific, and sex steroid hormones play a crucial role in determining such sexual dimorphisms [93, 94].”
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat (2005, result): “Moreover, in the present study, we showed that KiSS-1 mRNA expression is increased in the arcuate nucleus of the hypothalamus following castration in the male rat. These results indicate that KiSS-1 neurons are potential targets for feedback regulation by gonadal steroids and are in agreement with t”
Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. (2005, background): “Hypothalamic KiSS-1 expression is regulated by circulating sex steroids in rodents and primates, suggesting that kisspeptin is involved in the HPG negative feedback cycle (11, 15, 20, 22, 23).”