Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat

By M. Irwig, G. Fraley, Jeremy T. Smith, B. Acohido, S. Popa, M. Cunningham, M. L. Gottsch, D. Clifton, R. Steiner. Neuroendocrinology, 2005

923 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/c83a6d9c98ab49ffa298f633ea911b77e7d4b2d8

How researchers see this paper

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In Molecular Biology

1. D. Clifton
2. R. Steiner

In Reproductive Medicine

1. D. Clifton
2. R. Steiner

Citations in the corpus

• Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. (2005, methodology): “Double-label in situ hybridization for KiSS-1 mRNA/ER mRNA and KiSS-1/AR mRNA The cDNA template for the ER riboprobe was generated by PCR as previously described for GPR54 (13) with primers that were designed to contain promoters for T7 RNA polymerase in the antisense direction and T3 RNA polymerase”
• Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. (2015, background): “Kisspeptin, a product of Kiss1 gene, stimulates GnRH secretion and increases LH levels in mice [76, 77].”
• Kisspeptin signaling in the brain. (2009, background): “A more detailed examination of Kiss1r transcript in the forebrain has revealed expression in the DBB, medial septum, medial preoptic area, lateral preoptic area, median preoptic nucleus, anterior hypothalamus, and lateral hypothalamus (80).”
• Regulation of Kiss1 gene expression in the brain of the female mouse. (2005, methodology): “First, mutations and targeted deletions in GPR54 in humans and mice result in sexual infantilism and hypogonadotropic hypogonadism, caused by GnRH deficiency (16–18).”
• Kisspeptins and reproduction: physiological roles and regulatory mechanisms. (2012, background): “As a whole, these studies have conclusively demonstrated that a prominent population of Kiss1 neurons resides in the ARC, or the equivalent infundibular region in primates, as documented in the mouse, rat, hamster, guinea pig, shrew, sheep, horse, pig, monkey, and human, either in terms of expressio”
• Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. (2005, background): “FSH are blocked by GnRH antagonists (10, 16, 20).”
• Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse (2009, methodology): “Finally, GnRH neurons express both the kisspeptin receptor (Kiss1r) and NK3 (Irwig et al., 2004; Krajewski et al., 2005).”
• The pros and cons of phytoestrogens (2010, neutral): “AVPV kisspeptin neurons are more numerous in females than males and are thought to be essential for steroid positive feedback and the initiation of the preovulatory GnRH surge [125,264,226,93,114,46].”