Roles of PPARs in health and disease

By S. Kersten, B. Desvergne, W. Wahli. Nature, 2000

2,022 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/20558ecabdf3ab7c82877bd4c8060f2d2365cf2d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. S. Kersten
2. A. Chawla
3. Philippe Froguel
4. Toshimasa Yamauchi
5. D. Liao
6. Bart Staels
7. R. Evans
8. P. Tontonoz

In Physiology

1. U. Schibler
2. A. Chawla
3. Philippe Froguel
4. Toshimasa Yamauchi
5. D. Liao
6. P. Tontonoz
7. S. Kersten
8. J. Takahashi

Citations in the corpus

• Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. (2000, background): “Rhythmic expression has also been observed for enzymes involved in protein and amino acid metabolism, such as serine dehydratase (Ogawa et al. 1994), and transcription factors involved in fat metabolism, such as PPAR and spot 14 (Kinlaw et al. 1987; Lemberger et al. 1996; Kersten et al. 2000).”
• Ecotoxicology of human pharmaceuticals. (2006, background): “…been described; PPAR is involved in peroxisome proliferation and plays a pivotal role in controlling hepatic lipid metabolism (Schoonjans et al., 1996), whereas PPAR has diverse roles in basic lipid metabolism, and PPAR plays a key role in the differentiation of adipocytes (Kersten et al., 2000).”
• The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity (2001, methodology): “To this end, we used the PPAR-γ agonist rosiglitazone, which stimulates adipogenesis and at the same time reduces insulin resistanc”
• Activation of the peroxisome proliferator-activated receptor α protects against myocardial ischaemic injury and improves endothelial vasodilatation (2002, neutral): “olism of lipoproteins and fatty acids [1,2].”
• Therapeutic roles of peroxisome proliferator-activated receptor agonists. (2005, background): “In addition to being differentially distributed, PPAR isoforms vary in their selectivities and sensitivities to ligands and recruit distinct coactivator proteins, resulting in the regulation of different sets of genes (1).”
• Peroxisome Proliferator-Activated Receptor Alpha Target Genes (2010, background): “[2] S.”
• Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells (2001, background): “During the search for mediators of VPA teratogenicity, attention had been drawn to the peroxisome proliferator-activated receptors (PPARs) because VPA induces proliferation of peroxisomes in the rodent liver (Horie and Suga, 1985; GoÈttlicher et al., 1992; Kliewer et al., 1994; Kersten et al., 2000)”
• Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions (2007, neutral): “and peroxisome proliferator-activated receptor (PPAR)-α (refs”