Chronic granulomatous disease

By A. Towbin, Ian Chaves. Pediatric Radiology, 2010

989 citations recorded by the source corpus.

Subfields: Endocrinology, Immunology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/20462cfef3b3a5c1775bc78123fed7b6a203f3d2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

In Immunology

In Pulmonary and Respiratory Medicine

Citations in the corpus

Vitamin C and Immune Function (2017, background): “1 ROS, reactive oxygen species; NET, neutrophil extracellular trap.”
Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “, 2005) are generally accepted, it is still debated whether and to what extent ion fluxes that compensate for the activity of the NADPH oxidase contribute to the antibacterial effects of granule enzymes (Geiszt et al., 2001; Rada et al., 2004; Rada et al., 2005; Femling et al., 2006; Essin et al., 2”
Nox proteins in signal transduction (2009, positive): “Individuals lacking Nox2 or with mutations in other necessary components of the neutrophil NADPH oxidase are afflicted with CGD, and are highly susceptible to infection [44].”
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. (2010, positive): “aureus infections in patients with chronic granulomatous disease, who have a defect in neutrophil NADPH oxidase and respiratory burst (8).”
Reactive Oxygen Species in Inflammation and Tissue Injury (2014, neutral): “defective oxidase assembly and production of O2 - (177).”
The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities (2012, background): “NOX2-generated ROS are crucial for killing bound or ingested microbes, and NOX2-deficiency results in CGD, which is characterized by severe bacterial and fungal infections (98).”
Diverse stimuli engage different neutrophil extracellular trap pathways (2017, background): “These patients have mutations in genes coding for subunits of the NADPH oxidase complex and as such their neutrophils cannot make ROS (Heyworth et al., 2003).”
Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS‐modulating technologies for augmentation of the healing process (2017, background): “Moreover, as the removal of infectious agents is essential in preventing complicated, chronic wounds, GCD patients are prone to poor wound healing (28).”
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “Common infectious syndromes resulting from CGD include pneumonia and lung abscesses, and these patients are commonly infected by gram-positive bacteria (Staphylococcus aureus), gramnegative bacteria (Salmonella), and fungi (Aspergillus, Candida albicans) (Holland, 2013).”
The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, background): “There may also be continuous production of superoxide anion by vascular endothelium to neutralise nitric oxide, production of superoxide by other cells to regulate cell growth and differentiation, and the production of superoxide by phagocytic cells during the oxidative burst [6, 7].”
Chronic Granulomatous Disease: The European Experience (2009, background): “In contrast to p47 deficiency [13], most CGD patients with any of the other three forms have mutations unique to their families [14].”
Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants (2013, background): “O 2 ∙− is produced also by several cell types other than phagocytes, including lymphocytes and fibroblasts [82].”
Novel cell death program leads to neutrophil extracellular traps (2007, positive): “Patients with mutations in the NADPH oxidase suffer from chronic granulomatous disease (CGD; Heyworth et al., 2003).”