Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.
By P. Cheung, Ian P Salt, S. Davies, D. Hardie, David Carling. Biochemical Journal, 2000
684 citations recorded by the source corpus.
Subfields: Molecular Biology, Physiology, Surgery
View Paper: https://www.semanticscholar.org/paper/1ff0b24dcd4361006826e7431623a5e2026fa3f2
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Citations in the corpus
- AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol (2009, background): “One possible explanation is that in addition to the AMPK 2 activity, a crosstalk between the skeletal muscle and either the nervous system or fat, where the AMPK 1 isoform is predominant (17), is required for resveratrol-induced mitochondrial biogenesis or reduction of ROS in skeletal muscle.”
- AMPK in Health and Disease. (2009, methodology): “The mammalian AMPK domain limits were established experimentally by partial proteolysis (395), and a stable rat 1(68-163) fragment was expressed and crystallized in the presence of -cyclodextrin (an 1-4 linked heptaglucan), as had previously been performed for other starch binding domain structural ”
- Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. (2000, neutral): “Isoforms of all three subunits have been identified [6,7], but the physiological significance of the isoforms is unclear.”
- Intrasteric control of AMPK via the γ1 subunit AMP allosteric regulatory site (2004, background): “Photoaffinity labeling studies show AMP binding to the subunit (Cheung et al. 2000).”
- An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. (2007, background): “AMPK is a heterotrimeric protein kinase composed of a catalytic subunit (a) and two regulatory subunits (b and g) that sense low cellular energy levels by monitoring changes in the AMP:ATP ratio [8].”
- CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. (2004, methodology): “5 = 2–13 μM) and differed instead in their degree of stimulation by AMP (Figure 4b), in agreement with previous results obtained with native complexes prepared by immunoprecipitation (28).”