Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota.

By J. Bates, Janie Akerlund, E. Mittge, K. Guillemin. Cell Host and Microbe, 2007

715 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1fb1c314b65eb2667546a4f0f440cfe4361ed730

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Citations in the corpus

Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens (2010, background): “Interestingly, intestinal alkaline phosphatase has been shown to have a key role in detoxifying the LPS of commensal bacteria by dephosphorylating lipid A and preventing excessive inflammatory responses of IECs against the abundant LPS present in the gut lume”
Defining dysbiosis and its influence on host immunity and disease (2014, background): “, 2011), modification of bacterial products to make them less immunogenic (Bates et al., 2007), production of antibodies that can directly bind to and influence microbial function (Fagarasan and Honjo, 2003; Peterson et al.”
Evidence for a core gut microbiota in the zebrafish (2011, background): “…them to reveal host responses to the gut microbiota including effects on innate immunity, nutrient metabolism, and intestinal epithelial differentiation and renewal (Rawls et al., 2004, 2006; Bates et al., 2006, 2007; Cheesman and Guillemin, 2007; Cheesman et al., 2011; Kanther and Rawls, 2010).”
Teleost microbiomes: the state of the art in their characterization, manipulation and importance in aquaculture and fisheries (2014, background): “Experiments in zebrafish highlight the role that TLRs play in modulating intestinal microbiota, whereby alkaline phosphatase is produced via a TLR-4-myD88 controlled pathway to inhibit an inflammatory responses to gut microbiota (Bates et al., 2007).”
Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. (2010, background): “In zebra fish, endogenous IAP has been shown to have a protective role against LPS toxicity (6).”
Gut microbiota in health and disease. (2010, background): “One way to avoid this disastrous scenario is to minimize the toxic potential of LPS, which can be done via dephosphorylation of the LPS endotoxin component through the action of alkaline phosphatases, specifically the intestinal alkaline phosphatase (Iap) (18).”