The pancreatic stellate cell: a star on the rise in pancreatic diseases.
By M. B. Omary, Anson W. Lowe, S. Pandol, A. Lugea. Journal of Clinical Investigation, 2007
691 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/1f775f884e4fae64609554a53fa2e5052685588d
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Citations in the corpus
- Tumor-stroma interactions in pancreatic ductal adenocarcinoma (2007, background): “Further, activin-A, a member of the TGFh family, also functions in an autocrine manner to increase collagen I secretion and MMPs tissue inhibitors of MMPs and augment TGFh expression and secretion (19, 20), which regulate ECM turnover.”
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Diminished Survival (2014, neutral): “…a protective response from the host rather Cancer Cell 25, 719–734, June 16, 2014 ª2014 Elsevier Inc. 725 (legend on next page) 726 Cancer Cell 25, 719–734, June 16, 2014 ª2014 Elsevier Inc. than offering an oncogenic supportive role, as speculated (Armstrong et al., 2004; Omary et al., 2007).”
- Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy (2014, neutral): “A comparison of the transcriptomes of preactivated (3-day culture) and culture-activated (7 day culture) (Omary et al., 2007) PSCs isolated from healthy mouse pancreas revealed that, during activation, PSCs decrease expression of genes implicated in lipid storage and lipid metabolism, consistent wit”
- Mechanisms of hepatic fibrogenesis. (2008, neutral): “However, several new areas of rapid progress in the past 5–10 years also have taken root, including: (1) identification of different fibrogenic populations apart from resident stellate cells, for example, portal fibroblasts, fibrocytes, and bone-marrow– derived cells, as well as cells derived from e”
- Stromal biology and therapy in pancreatic cancer (2010, background): “EGFR is frequently overexpressed in pancreatic cancer and correlates with poor prognosis and disease progression.91 EGFR signalling has also been shown to impact pancreatic stromal reaction by activating PSCs.92 The combination of gemcitabine and erlotinib conferred a marginal but significant improv”
- The Pancreas Cancer Microenvironment (2012, background): “changes, increased proliferation, deposition of ECM, and expression of a-smooth muscle actin (a-SMA) as well as the loss of the fat droplets (19).”
- Astrocytes: biology and pathology (2009, background): “For example, there is increasing evidence that GFAPexpressing pancreatic stellate cells play important roles in tissue repair, fibrosis, and scar formation [176].”
- Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “For instance, in liver and pancreatic cancer models, quiescent pancreatic stellate cells (PSCs) and hepatic stellate cells (HSCs) express CAF-like surface markers such as α-SMA upon activation with TGF-β and PDGF, which convert them into activated CAFs [41, 42].”