Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.

By R. Bachoo, E. Maher, K. Ligon, N. Sharpless, Suzanne S Chan, M. J. You, Yi Tang, Jessica DeFrances, E. Stover, Ralph Weissleder and 3 more. Cancer Cell, 2002

715 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Genetics

View Paper: https://www.semanticscholar.org/paper/1f4d1f398962d20398adc08547faa9c4c86ce00c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. D. Louis
2. Mauro Delorenzi
3. S. Morrison
4. D. Tuveson
5. Alec C. Kimmelman
6. Kenneth D. Aldape
7. R. DePinho

In Developmental Neuroscience

1. Shenghui He
2. S. Morrison
3. R. DePinho
4. P. Dirks

In Genetics

1. William C. Hahn
2. Mauro Delorenzi
3. S. Morrison
4. R. DePinho

Citations in the corpus

• Epidermal growth factor receptor: mechanisms of activation and signalling. (2003, background): “[217]; EGFR activation in INK4a/Arf-deficient mice leads to dedifferentiation of astrocytes and is instrumental in gliomagenesis.”
• Identification of a cancer stem cell in human brain tumors. (2003, background): “ers suggest that a differentiated neural cell is equally permissive to transformation if it has a key genetic alteration (27).”
• Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007, background): “…GBM cells by reducing apoptosis and increasing proliferation (Nishikawa et al. 1994; Nagane et al. 1996; Huang et al. 1997; Narita et al. 2002) and to malignantly transform murine Ink4a/Arf-null neural stem cells (NSCs) or astrocytes in the mouse brain (Holland et al. 1998a; Bachoo et al. 2002).”
• Isolation of cancer stem cells from adult glioblastoma multiforme (2004, background): “…mixed glioblastomas may develop from neural stem cells (NSCs) or from differentiated cell types that acquired multipotential stem cell-like properties by either reprogramming or de-differentiating in response to oncogenic mutation (Kondo and Raff, 2000; Bachoo et al., 2002; Zhu and Parada, 2002).”
• Mosaic Analysis with Double Markers (MADM) Reveals Tumor Cell-of-Origin in Glioma (2011, neutral): “However, other studies suggest that NSC-derived progeny such as astrocytes or oligodendrocyte precursor cells (OPCs) might directly transform (Bachoo et al., 2002; Lindberg et al., 2009; Persson et al., 2010).”
• Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. (2006, background): “Loss of chromosome (chr) 10q is a more frequent occurrence in GBM than AA and has been associated with short GBM survival (Balesaria et al., 1999; Schmidt et al., 2002; Smith et al., 2001).”
• Cancer stem cells in nervous system tumors (2004, background): “The same researchers also suggest that a differentiated neural cell such as an astrocyte may be equally permissive to transformation as a progenitor, if it has a key genetic alteration such as loss of tumor suppressor Ink4a-Arf (Bachoo et al., 2002; Uhrbom et al., 2002).”