Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages.

By Steven J. Kattman, Tara L. Huber, G. Keller. Developmental Cell, 2006

773 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1f1b8232d867f7867dfbf1d1b4909b26435f0628

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In Molecular Biology

Citations in the corpus

MicroRNA-133 controls cardiac hypertrophy (2007, background): “However, MyoD and myogenin are not expressed in the heart (ref”
The developmental genetics of congenital heart disease (2008, background): “Intriguingly, the cardiovascular lineages — myocardial, endocardial and smooth muscle — all derive from common precursors that sequentially branch off as specialized cell type”
Cardiomyocyte A Disintegrin And Metalloproteinase 17 (ADAM17) Is Essential in Post–Myocardial Infarction Repair by Regulating Angiogenesis (2015, background): “VEGFR2-positive cardiomyocyte progenitor cells have also been reported to contribute to the formation of the cardiomyocytes and endothelial cells.(33) It is plausible that after tissue injury, as a part of recapitulation of fetal gene expression pattern, such progenitor cells are migrated to and pro”
Braveheart, a long non-coding RNA required for cardiovascular lineage commitment (2013, background): “Together, PdgfRa and Flk-1 define an early multipotent cardiovascular progenitor population (marked by MesP1), and their coexpression enhances cardiogenic potential (Kattman et al., 2006; Yang et al., 2008).”
Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors (2010, methodology): “For aMHC-GFP/cTnT expression, cells were fixed with 4% PFA for 15 min, permeabilized with Saponin, and stained with anti-cTnT and anti-GFP antibodies, followed by secondary antibodies conjugated with Alexa 488 and 647 (Kattman et al., 2006).”
Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. (2008, methodology): “Fluorescence-activated cell sorting (FACS) has been used to select many ESC derivatives, including hematopoietic cells, mesodermal progenitors, and endothelial cells (Gadue et al., 2006; Kattman et al., 2006; Kouskoff et al., 2005; Wang et al., 2004).”