A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

By K. Akashi, D. Traver, T. Miyamoto, Irving L. Weissman. Nature, 2000

2,822 citations recorded by the source corpus.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/1f15a73fd298c0ee92849d40dcbad66118705efa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. J. Dick
2. Daniel G. Tenen
3. Derrick J. Rossi
4. Irving L. Weissman
5. Frank Rosenbauer
6. Linheng Li
7. A. Trumpp
8. David Bryder

In Immunology

1. Steffen Jung
2. A. Mildner
3. P. Italiani
4. D. Boraschi
5. M. Guilliams
6. F. Geissmann
7. M. Pittet
8. Eric G. Pamer

Citations in the corpus

• Lineage tracing on transcriptional landscapes links state to fate during differentiation (2018, background): “Cell culture and transplantation studies over several decades have led to the prevailing model of hematopoiesis as a branching hierarchy with defined faterestricted intermediates (8).”
• Phagocyte partnership during the onset and resolution of inflammation (2010, background): “Their partnership begins in the bone marrow, where they arise from a common precurso”
• Monocytes give rise to mucosal, but not splenic, conventional dendritic cells (2007, background): “Monocytes are known to originate in the BM from a granulocyte-myeloid precursor (9).”
• c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. (2004, methodology): “…on HSC differentiation in vivo is direct or is dependent on their location in the BM microenvironment/niche, KLS-HSCs were isolated and bulk cultured in vitro in the presence of a differentiation permitting cytokine cocktail containing IL-3, IL-11, SCF, TPO, Flt3L, GM-CSF, EPO (Akashi et al. 2000).”
• Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. (2001, methodology): “For example, 8% of the LT-HSC enter the cell cycle per day at random, whereas higher percentages of ST-HSC, MPP, CLP, and CMP enter the cell cycle each day (Morrison & Weissman 1994, Kondo et al. 1997, Akashi et al. 2000, Cheshier et al. 1999).”
• DISTINCT ROUTES OF LINEAGE DEVELOPMENT RESHAPE THE HUMAN BLOOD HIERARCHY ACROSS ONTOGENY (2015, background): “For example, simultaneous expression of molecular factors associated with My-Er-Mk lineages at low levels is considered to maintain CMPs as the origin of the common lineage for myelopoiesis (3).”