Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

By Kenny K K Chung, Yi Zhang, K. Lim, Yuji Tanaka, Hui-li Huang, Junqing Gao, Christopher A. Ross, Valina L. Dawson, T. Dawson. Nature Medicine, 2001

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Molecular pathophysiology of Parkinson's disease. (2005, background): “…have been reported for parkin on the basis of in vitro and cell culture experiments, including CDCrel- 1 (Zhang et al. 2000), synphilin-1 (Chung et al. 2001b), a rare O-glycosylated form of α-synuclein (Shimura et al. 2001), the parkin-associated endothelin receptor-like receptor…”
Pathological roles of MAPK signaling pathways in human diseases. (2010, background): “the ubiquitination of several substrates including cyclin E [100], synphilin [101], and LIM kinase 1 [102].”
Parkinson's Disease Mechanisms and Models (2003, background): “Expression of this proline mutant form synuclein function (Shimura et al., 2001; Petrucelli et al., of DJ-1 appears to lead to its accumulation in mitochon2002) or aggregation (Chung et al., 2001).”
The clinical symptoms of Parkinson's disease (2016, background): “It is estimated that up to 80% of dopaminergic cells in the nigro-striatal system are lost before the cardinal motor features of PD start to appear (Chung et al. 2001).”