Targeted ablation of the 25-hydroxyvitamin D 1α-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction
By D. Panda, D. Miao, M. Tremblay, J. Sirois, R. Farookhi, G. Hendy, D. Goltzman. Proceedings of the National Academy of Sciences of the United States of America, 2001
617 citations recorded by the source corpus.
Subfields: Endocrinology, Diabetes and Metabolism, Orthopedics and Sports Medicine, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/1e260c5be6883f755243c2a567cdb9a0357b9b8a
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In Endocrinology, Diabetes and Metabolism
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Citations in the corpus
- Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. (2005, neutral): “deficient in peripheral T lymphocytes (7).”
- 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. (2002, methodology): “Twenty-four hours after transfection, the cells were treated for 24 hours with 5 × 10–8 M 1,25(OH)2D3 or ethanol in serum-free media, or with different doses of bovine PTH(1-34) as indicated.”
- Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, background): “The expression of PMCA1b was unaltered, irrespective of the genotype (155, 157, 158, 160, 164, 176).”
- Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. (2013, background): “This has been achieved by ablating CYP27B1 (Dardenne et al., 2001; Panda et al., 2001).”
- The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, background): “Second, this phenotype is recapitulated in the heritable conditions of vitamin D resistance and impaired receptor function where muscle weakness, bone pain, and poor skeletal mineralization are quite common (73, 127, 129).”
- Vitamin D and Immune Function (2013, result): “In vitro data are also supported by results from VDR and CYP27B1 knockout mice which show significantly increased numbers of mature DC and abnormal DC chemotaxis [69–71].”