1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system.
By Y. Li, J. Kong, Minjie Wei, Zhoudao Chen, Shu Q. Liu, Li-ping Cao. Journal of Clinical Investigation, 2002
1,047 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/ad8ee6da46cb4ece0a154321e0e4d972bea4dd4f
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- Zhongyi Zhang
Citations in the corpus
- Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. (2007, result): “It is also known that 1,25-dihyroxyvitamin D levels are indirectly associated with serum renin levels in hypertensive subjects,(19) a finding that was recently corroborated in vitamin D receptor knockout mice.(20) Elevated PTH is known to cause cardiomyocyte damage in animals with CKD(21) and parath”
- Vitamin D and cardiovascular disease. (2014, background): “by 1,25(OH) 2 D via reduction in the activity of the cAMP response element in the renin gene promoter.(89,90) In the VDR”
- 25-hydroxyvitamin D levels and the risk of mortality in the general population. (2008, background): “In mice, vitamin D is an inhibitor of the renin-angiotensin system.(1) Other inhibitors of the renin-angiotensin system, such as angiotensinconverting enzyme inhibitors, reduce mortality and morbidity in multiple disease states.”
- Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. (2005, methodology): “Blood pressure of VDR(-/-) mice is about 20 mmHg higher than that of WT mice, but blood electrolyte levels of the mutant mice are normal (19).”
- Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. (2008, methodology): “Western blot analysis was performed as described previously (21).”
- Resurrection of vitamin D deficiency and rickets. (2006, unknown): “Li et al. (112) reported that 1,25(OH) 2 D 3 is an effective regulator of renin production, which controls blood pressure.”