NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

By Samantha W. Alvarez, Vladislav O. Sviderskiy, Erdem M. Terzi, T. Papagiannakopoulos, A. Moreira, S. Adams, David M. Sabatini, Kıvanç Birsoy, Richard L. Possemato. Nature, 2017

676 citations recorded by the source corpus.

Subfields: Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/1dcbcd3e0fd769cb2d0594bc7d79d71fb2c7d4f5

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In Molecular Biology

1. D. Tang
2. R. Kang
3. Xin Chen
4. M. C. Simon
5. W. Zou
6. W. Gu
7. P. Lei
8. Arul M. Chinnaiyan

In Pulmonary and Respiratory Medicine

1. D. Tang
2. R. Kang
3. Xin Chen
4. M. C. Simon
5. W. Gu
6. P. Lei
7. Furong Zeng
8. Yu Meng

Citations in the corpus

• Iron Metabolism in Ferroptosis (2020, background): “The activation of BACH1 enhances erastininduced ferroptosis through transcriptional downregulation of FTH1, FTL, and SLC40A1 (Nishizawa et al., 2020).”
• Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, methodology): “Current models mainly rely on the use of FINs, such as IKE and cyst(e)inase, 43,53,192,465,496 to treat xenograft tumors.”
• Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. (2022, neutral): “Abbreviations: AA, arachidonic acid; ALOXs, lipoxygenases; BAP1, ubiquitin carboxyl-terminal hydrolase; CoA, coenzyme A; GPX4, glutathione peroxidase 4; IFNg, interferon gamma; MLL4, histone-lysine N-methyltransferase 2B; NFS1, cysteine desulfurase, mitochondrial; p53, p53 tumor suppressor protein; ”
• The cell biology of ferroptosis (2024, neutral): “S clusters, triggering a feedback iron starvation response that increases iron import and heightens ferroptosis sensitivity 92 .”
• Glutathione metabolism in cancer progression and treatment resistance (2018, background): “Suppression of cysteine desulfurase (NFS1) induces an iron starvation response, which can trigger this kind of cell death when exposed to ROS (Alvarez et al., 2017).”
• CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy (2019, background): “Cyst(e)inase, an engineered enzyme that degrades cystine as well as cysteine, efficiently induces oxidative stress and results in cell death 21,22 .”
• Ferroptosis: mechanisms and links with diseases (2021, background): “Inhibition of NFS1, a [Fe–S] cluster biosynthetic enzyme, stimulates the expression of transferrin receptor but restrains ferritin, causing iron-starvation response and leading to ferroptosis in lung cancer cells.(8) Salinomycin has been reported to kill cancer stem cells in a mechanism involving ir”