miR-181a is an intrinsic modulator of T cell sensitivity and selection.

By Qi-jing Li, J. Chau, Peter Ebert, Giselle Sylvester, Hyeyoung Min, Gwen Liu, Ravi Braich, M. Manoharan, Juergen Soutschek, Petra Skare and 3 more. Cell, 2007

1,235 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/1dbf5312560cd8b0c771673025e1cf586f792419

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Citations in the corpus

Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges (2010, neutral): “One of the most appealing properties of miRNAs as therapeutic agents is their ability to target multiple genes, frequently in the context of a network, making them extremely efficient in regulating distinct biological cell processes relevant to normal and malignant cell homeostasi”
The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (2008, background): “Previous studies have supported a role for miRNAs in biologically important partial, as opposed to complete, suppression of target mRNAs (Sevignani et al., 2006; Ying et al., 2006; Li et al., 2007).”
microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells (2007, result): “Such a view is consistent with recent reports of the role of mir-181a in setting the threshold for T-cell receptor signal transduction through the regulation of multiple phosphatases (Li et al., 2007)or in the regulation of cardiogenesis by miRNA-1-2(Zhao et al., 2007).”
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells (2011, background): “For example, specific miRNAs such as miR-155 and miR-181 regulate both the immune response and immune system developmen”
MicroRNAs in development and disease. (2011, background): “miR-181 is also enriched in the thymus, where it is high during the early stages of T-cell differentiation and gradually declines to its lowest level in Th1 and Th2 cells (359).”
Immunosenescence: molecular mechanisms and diseases (2023, background): “The decline in miR-181a is thought to be an example of antagonistic pleiotropy; it is beneficial for T-cell development in young adults and prevents autoimmune diseases, but the decreased expression of miR-181a during aging leads to its diminished inhibitory effect, and the expression of dual-specif”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “In addition, it was shown to modulate the intrinsic sensitivity of T cells to antigen by targeting a number of phosphatases that are known negative regulators of T-cell responses (Li et al., 2007).”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “miR-181a, which is increased during early T cell development, enhances TCR signalling strength by directly targeting a group of protein phosphatases, including dual-specificity protein phosphatase 5 ( DUSP5 ), DUSP6 , SH2-domain-containing protein tyrosine phosphatase 2 ( SHP2 ; also known as PTPN”
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. (2008, background): “It has been found that miRNA modulate T cell selection and T cell receptor sensitivity ( 13 ) as well as Treg cell development (14), which may suggest that miRNA are also involved in the development of autoimmunity.”
The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ (2011, background): “For example, miR-181a and miR-182 are important in modulating T cell developmen”
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways (2008, neutral): “…had not been conﬁrmed for most miRNAs in the enrichment pathways, we did observe that miRNAs linked to immune cell functions including innate immunity (e.g. miR-146b) [62] and T cell activation and differentiation (e.g., miR-181a, miR-142) (Table 4) [10,40,49] were frequently represented.”