Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation.

By F. Long, Xiaoyan M. Zhang, S. Karp, Yingzi Yang, Andrew P. McMahon. Development, 2001

690 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1d50e4a95138bdf397e7eb1dbd0eb222568ea17d

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Fanxin Long
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Matthew J. Hilton
Xiaolin Tu

Citations in the corpus

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors (2006, methodology): “Col2 1-cre3 (Long et al., 2001), -cateninc/c (Brault et al., 2001), Catnbloxex3/loxex3 (Harada et al., 1999), -catenin+/n (Haegel et al., 1995), Smoc/c, Smo+/n (Long et al., 2001) and Sox2-cre (Hayashi et al., 2002) mouse lines have been described previously.”
Sequential roles of Hedgehog and Wnt signaling in osteoblast development (2004, methodology): “The Smo* cDNA was as previously described (Long et al., 2001).”
Indian Hedgehog: A Mechanotransduction Mediator in Condylar Cartilage (2004, background): “It was demonstrated that Ihh up-regulates the expression of cyclin D1, a kinase that controls the “pass” of restriction point in the G1 phase by up-regulating a group of regulatory factors necessary for the transition from the G1 to the S phase (Twyman, 1998; Long et al., 2001).”
Development of the endochondral skeleton. (2013, background): “Subsequent genetic manipulation of Smo in chondrocytes revealed that direct IHH input was required for chondrocyte proliferation (Long et al. 2001), but not for the regulation of chondrocyte hypertrophy.”
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development (2003, background): “Ihh, which coordinates the progression of chondrocytes to hypertrophy and promotes cell proliferation (Long et al., 2001; St-Jacques et al., 1999), is expressed in a pattern overlapping that of Ctgf.”
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons (2007, methodology): “Conditional (floxed) Smo mice (Smoc/c) were a gift from Andrew McMahon and were genotyped as described previously (Lewis et al., 2001; Long et al., 2001).”
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. (2003, unknown): “A constitutively null allele of Smo (Smonull) has also been described (Zhang et al., 2001).”