Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors.

By Yan-You Huang, Eleanor H. Simpson, C. Kellendonk, E. Kandel. 2004

238 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, positive): “Taken together, these findings indicate that neuromodulation in the mushroom body instructs opposing forms of synaptic plasticity, analogous to the bidirectional tuning of synaptic strength by dopamine in mammalian brain centers (Huang et al., 2004; Shen et al., 2008; Tritsch and Sabatini, 2012).”
Extraordinary neoteny of synaptic spines in the human prefrontal cortex (2011, background): “The magnitude of dopaminergic innervation in the monkey and human cortex, including gene expression of the D1-receptor that is essential for the bidirectional modulation of synaptic plasticity in the medial prefrontal cortex (60), increases up to young adulthood (61) and reaches its highest level du”
Intrinsically motivated action-outcome learning and goal-based action recall: a system-level bio-constrained computational model. (2013, background): “It is important to notice that all the neural connections considered here undergo learning processes, and these might be enhanced or made possible by neuromodulators such as DA (Huang et al., 2004; Otani et al., 2003).”
Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. (2007, background): “In fact, glutamatergic synapses onto NAc MSNs do exhibit both long-term potentiation (LTP) and long-term depression (LTD).”
A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescales. (2007, background): “The cortico-striatal pathway is known to exhibit synaptic plasticity that is strongly modulated by dopamine signals (Reynolds et al., 2001; Reynolds and Wickens, 2002); there is also evidence that dopamine influences long-term synaptic plasticity in prefrontal neurons (Otani et al., 2003; Huang et ”
Sleep facilitates memory by blocking dopamine neuron mediated forgetting (2015, unknown): “DA is known to regulate various types of plasticity in mammals (Li et al., 2003; Huang et al., 2004; Centonze et al., 2001).”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “Although dopamine appears to influence LTP and LTD in the PFC (Otani et al. 1998; Gurden et al. 1999, 2000; Huang et al. 2004), little is known about the mechanisms by which addictive drugs modify synaptic properties in this region.”
Reinforcement Learning Through Modulation of Spike-Timing-Dependent Synaptic Plasticity (2007, background): “It is known that dopamine and acetylcholine modulate classical (firing rate dependent) long term potentiation and depression of synapses (Seamans and Yang, 2004; Huang et al., 2004; Thiel et al., 2002).”
Neural mechanism for stochastic behaviour during a competitive game (2006, unknown): “ganglia provides a candidate circuit for action selection ( Houk, Davis, & Beiser, 1995; Redgrave, Prescott, & Gurney, 1999; Reynolds & Wickens, 2002).”
Multiple dopamine functions at different time courses. (2007, background): “…processes, including changes in appetite, hunger, satiation, behavioral excitation, aggression, mood, fatigue, despair, sleepiness, maintenance of hippocampal plasticity, or memory consolidation to which the speed of microdialysis is better matched (Packard & White 1991, Huang et al. 2004).”