Extraordinary neoteny of synaptic spines in the human prefrontal cortex

By Z. Petanjek, M. Judas, G. Šimić, Mladen-Roko Rasin, Harry B. M. Uylings, P. Rakic, I. Kostović. Proceedings of the National Academy of Sciences of the United States of America, 2011

1,287 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/1f3a53ea9a5f7ff2de68a2ca39546da7ae142fc7

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Brain Plasticity and Human Evolution (2017, positive): “…for environment-dependent brain maturation in adolescence and early adulthood, during which important processes, such as myelination (Miller et al. 2012) and continued developmental pruning of synaptic spines on pyramidal neurons in the prefrontal cortex (Petanjek et al. 2011), are known to occur.”
Is adolescence a sensitive period for sociocultural processing? (2014, background): “Anatomical studies of postmortem human brain tissue provided some of the first evidence that the brain undergoes profound changes in anatomy across the first decades of life (Petanjek et al. 2011, Webb et al. 2001, Yakovlev & Lecours 1967).”
The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016, positive): “…earliest organ systems of the human body to begin its development prenatally and among the last to complete it postnatally; development continues into the mid-20s or perhaps even the 30s in certain regions and neural circuits (Gogtay et al., 2004; Petanjek et al., 2011; Yakovlev and Lecours, 1967).”
Adolescence as a neurobiological critical period for the development of higher-order cognition (2018, positive): “, 2014), and synapse proliferation (Bourgeois et al., 1994; Huttenlocher, 1990; Petanjek et al., 2011), indicate a period of significant plasticity and neurodevelopment that extends into adulthood.”
Prolonged myelination in human neocortical evolution (2012, background): “In addition, synapse maturation (3, 4) and axonmyelination (5, 6) occur during later life history stages in humans compared with macaques.”
The effects of social deprivation on adolescent development and mental health (2020, positive): “Thus, the heightened neuroplasticity that characterises early development(24) is proposed to continue into adolescence(20, 21, 23).”
Schizophrenia risk from complex variation of complement component 4 (2016, background): “Synapse elimination in human association cortex appears to continue from adolescence into the third decade of life 39 .”
Development of the Cerebral Cortex across Adolescence: A Multisample Study of Inter-Related Longitudinal Changes in Cortical Volume, Surface Area, and Thickness (2017, background): “A second hypothesis is that synaptic pruning and dendritic arborization (Bourgeois and Rakic, 1993; Huttenlocher and Dabholkar, 1997; Petanjek et al., 2011) results in decreasing gyrification and flattening of the cortex during adolescence (Raznahan et al.”