Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.

By Shitij Kapur. American Journal of Psychiatry, 2003

2,768 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Psychiatry and Mental health, Philosophy

View Paper: https://www.semanticscholar.org/paper/1d2658a53f1bc9cd64a86a1f1f6b9c130921e0bd

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Citations in the corpus

Neural correlates of the LSD experience revealed by multimodal neuroimaging (2016, background): “The altered meaning factor of the ASC is composed of items such as “some unimportant things acquired a special meaning” and “things in my surroundings had a new or alien meaning” that are phenomenologically resonant with the notion of “aberrant salience” in schizophrenia research (38).”
Multi-Site Diagnostic Classification of Schizophrenia Using Discriminant Deep Learning with Functional Connectivity MRI (2018, background): “…1995; Reith et al., 1994), i.e., dysregulated dopamine transmission may cause improper assignment of salience to irrelevant stimulus externally or internally, leading to delusional thought and hallucinations, respectively (Braff, 1993; Cohen and Servan-Schreiber, 1992; Kapur, 2003).”
From prediction error to incentive salience: mesolimbic computation of reward motivation (2012, background): “Related reversals of valence may be clinically involved in schizophrenia or drug psychosis, where enhancements of fearful motivation toward some stimuli may transition to enhanced appetitive motivation toward other stimuli, or from appetitive to aversive (Kapur, 2003; van Os & Kapur, 2009; Buckholtz”
Glutamate and dopamine in schizophrenia: an update for the 21st century (2015, background): “The aberrant salience model (Heinz and Schlagenhauf, 2010; Kapur, 2003; WintonBrown et al., 2014) seeks to provide this link.”
Synaptic plasticity and dysconnection in schizophrenia. (2006, background): “In contrast to the sparse evidence for abnormal connectivity at the level of cellular processes, pharmacological studies of healthy volunteers show that impairments of synaptic plasticity are consistent with schizophrenic symptoms (Table 2).”
The Computational Anatomy of Psychosis (2013, background): “, and Kapur, S. (2009). The dopamine hypothesis of”
A Cybernetic Theory of Psychopathology (2018, background): “A process of “aberrant salience” may help to explain why people high in Openness and at risk for psychosis are prone to detecting patterns erroneously, if dopamine signals that valuable information is present even when that is highly unlikely (DeYoung et al., 2012; Kapur, 2003).”
Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications (2005, background): “This review focuses on what Kapur, in a paper presented later (28), calls psychosis-in-schizophrenia .”
Dopamine, Affordance and Active Inference (2012, background): “By associating salience with precision we can also connect to constructs like incentive salience in psychology [47] and aberrant salience in psychopathology [48].”
Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia. (2011, background): “The third region was in the midbrain, and incorporated monoamine neuronal centers implicated in the pathophysiology of schizophrenia (60,61).”
Drosophila strategies to study psychiatric disorders. (2013, background): “sense of aberrant salience attributed to random events in the environment [88,166].”
The dopamine hypothesis of schizophrenia: version III--the final common pathway. (2009, neutral): “Psychosis is, therefore, aberrant salience driven by dopamine and filtered through the individual’s existing cognitive and sociocultural schemas—thus allowing the same chemical (dopamine) to have different clinical manifestations in different cultures and different individuals.(159,160) Incentive sa”
‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders (2009, background): “weight gain and remaining thin), and mesolimbic desires and dreads can even co-exist or feed off one another [155,172,173].”